Follicular phase

Carcinoma

Thyroid carcinoma

Estrogen receptor beta

Multivariate analysis

Estrogen

Receptor

Progesterone receptor

Cancer research

Lymph node

Estrogen receptor

Estrogen receptor alpha

Epidermal growth factor receptor

Internal medicine

Univariate analysis

Oncology

Medicine

Immunohistochemistry

Breast cancer

Cancer

Pathology

Thyroid

Journal of Thyroid Research

The primary aim of this study was to determine the incidence of estrogen receptor α (ERα), estrogen receptor β (ERβ), and human epidermal growth factor receptor 2 (HER-2) expression in various subtypes of thyroid carcinoma (TC) of follicular origin and the secondary aim was to correlate the expression with various clinicopathologic prognostic factors.Immunohistochemistry analysis was performed on archival paraffin-embedded tissue sections (1991-2016). ERα, ERβ, and HER-2 expressions were correlated with clinicopathologic prognostic factors, disease recurrence, and overall survival (OS).A total of 264 TC patients were included in the study. Incidences of ERα, ERβ, and HER-2 were 8.1 vs 16.3 vs 13.9% (p=0.15), 26.6 vs 11.5 vs 36.1% (p=0.002), and 12.9 vs 2.9 vs 0% (p=0.003) in papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), and poorly differentiated thyroid carcinoma (PDTC), respectively. Overall ERα had significant correlation with distant metastases (0.038) and in case of PDTC with multicentricity (p=0.037). ERβ had significant correlation with lymph node metastases (p=0.023) in FTC. HER-2 correlated with tumor size (p=0.027) only on univariate analysis. OS did not correlate with expression of any receptor.ERα, ERβ, and HER-2 have differential expression and prognostic implications in different TC subtypes.

Distribution and Prognostic Significance of Estrogen Receptorα(ERα), Estrogen Receptorβ(ERβ), and Human Epidermal Growth Factor Receptor 2 (HER-2) in Thyroid Carcinoma