Abstract Ethnopharmacological relevance Danggui Buxue Tang (DBT) has been used to promote hematopoiesis and relieve myelosuppression in China. Antibiotics can cause myelosuppression through gut microbiota disorders. Aim of the study: This study aims to explore the way of DBT to alleviate the metabolic disorder caused by antibiotics. Materials and methods In this study, 16S rRNA sequencing was used to detect the change of gut microbiota, metabolomics to analyze the change of metabolites. Correlation analysis was used to establishment the correlation between gut microbiota and metabolites. PICRUST 2 was used to predict the function of gut microbiota. Results Results showed that eighty-two genera of gut microbiota were affected by antibiotic, while twelve were significantly restored after DBT. Seventy-four potential metabolites were significantly different from the antibiotics and DBT. We found significant recovery by the Bacteroides and Rikenellaceae RC9 after DBT. The metabolic pathways influenced by the antibiotic treatment included primary and secondary bile biosynthesis, etc. The metabolic pathways that could be restored after DBT included the primary and secondary bile acid biosynthesis pathway, etc. Through correlation analysis, we found a correlation between the Bacteroides, Rikenellaceae_RC9_gut_group and other potential differential metabolisms such as those of taurodeoxycholic acid, N-phenylacetyl glycine, etc. The functional prediction showed that the biosynthesis of primary bile acid, secondary bile acid was significantly affected. Conclusions DBT can restore the gut and reverse the metabolic disorder caused by antibiotics through Bacteroides, and it provides a new medical idea regarding the gut microbiota balance.
Abstract Azolla imbricata (Roxb.) Nakai is used as a traditional Chinese medicine. However, very limited information is available on its effective components. Traditional procedures for discovering natural bioactive compounds, especially for minor ones, are usually time-consuming and labor-intensive. Therefore, an efficient approach using ultra-high performance liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (UHPLC–QTOF–MS/MS) combined with multicomponent knockout and bi...
Last. Guo Jiao(Guangdong Pharmaceutical University)H-Index: 2
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Abstract Background/Aims Fufang Zhenzhu Tiao Zhi (FTZ) capsule is a Chinese herbal preparation under the guidance of professor Guo Jiao’s new theory of “Tiaogan Qishu Huazhuo” for disorders of glucose and lipid metabolism for more than twenty yares, which has been demonstrated to exhibit potential anti-aging effects such as regulation of glucose and lipid metabolisms and antiinflammatory and antioxidative effects. This study attempts to reveal the anti-intestinal aging effect and possible mechan...
Recently, increasing evidence has suggested the association between gut dysbiosis and Alzheimer’s disease (AD) progression, yet the role of gut microbiota in AD pathogenesis remains obscure. Herein, we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression. Using AD mouse models, we discovered that, during AD progression, the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine, which ...
#1Shanpeng Ma(LNUTCM: Liaoning University of Traditional Chinese Medicine)H-Index: 1
#2Yujun Jiang(LNUTCM: Liaoning University of Traditional Chinese Medicine)H-Index: 1
Last. Qian Cai(LNUTCM: Liaoning University of Traditional Chinese Medicine)H-Index: 4
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Atractylodis Rhizoma (AR), a kind of well-known traditional Chinese medicine (TCM), has a long history of being used to treat spleen-deficiency syndrome (SDS). Stir frying with bran is a common method of processing AR, as recorded in the Chinese Pharmacopoeia, and is thought to enhance the therapeutic effect in TCM. Our previous studies have confirmed that bran-fried AR is superior to raw AR in terms of the improvement of gastrointestinal tract function. However, the biological mechanism of acti...
#1Alfonso León-Del-Río(UNAM: National Autonomous University of Mexico)H-Index: 10
: Biotin is a water-soluble vitamin that belongs to the vitamin B complex and which is an essential nutrient of all living organisms from bacteria to man. In eukaryotic cells biotin functions as a prosthetic group of enzymes, collectively known as biotin-dependent carboxylases that catalyze key reactions in gluconeogenesis, fatty acid synthesis, and amino acid catabolism. Enzyme-bound biotin acts as a vector to transfer a carboxyl group between donor and acceptor molecules during carboxylation r...
#2Wei-Rui Goh(NUS: National University of Singapore)H-Index: 1
Last. Yuan-Kun Lee(NUS: National University of Singapore)H-Index: 2
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Abstract Trillions of microbes have evolved with and continue to live on human beings. With the rapid advances in tools and technology in recent years, new knowledge and insight in cross-talk between the microbes and their hosts have gained. It is the aim of this work to critically review and summarize recent literature reports on the role of microbiota and mechanisms involved in the progress and development of major human diseases, which include obesity, hypertension, cardiovascular disease, di...
#1Kenneth Kin Leung Kwan(HKUST: Hong Kong University of Science and Technology)H-Index: 5
#2Yun Huang(HKUST: Hong Kong University of Science and Technology)H-Index: 5
Last. Karl Wah Keung Tsim(HKUST: Hong Kong University of Science and Technology)H-Index: 60
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Danggui Buxue Tang (DBT) is an ancient herbal mixture containing Astragali Radix and Angelicae Sinensis Radix, and which is a commonly consumed for “Qi-invigorating” as a traditional Chinese medicine (TCM). The pharmacological activities of DBT in anti-oxidation, estrogenic, hematopoietic and immunogenic have been reported; however, the role of DBT in energy metabolism in cellular level has not been determined. Here, we employed an extracellular flux analyzer to evaluate the mitochondrial respir...
#1Xu-Qin Shi(Nanjing University of Chinese Medicine)H-Index: 11
#2Shi-Jun Yue(Shaanxi University of Chinese Medicine)H-Index: 5
Last. Jin-Ao Duan(Nanjing University of Chinese Medicine)H-Index: 55
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Abstract Ethnopharmacological relevance Danggui buxue Decoction (DBD) has been frequently used to treat with blood deficiency, which consisted of Danggui (DG) and Huangqi (HQ) at a ratio of 1:5. Accumulating evidence showed that blood deficiency in traditional Chinese medicine (TCM) was similar to anemia in modern medicine. Aim of the study The purpose of this study was to explore its therapeutic mechanism of with network pharmacology approach. Materials and methods We explored the chemical comp...
#1Meiling Sun(HMU: Harbin Medical University)H-Index: 2
#2Bing Du(HMU: Harbin Medical University)H-Index: 1
Last. Bingrong Liu(HMU: Harbin Medical University)H-Index: 2
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: BACKGROUND Ulcerative colitis is a chronic, idiopathic inflammatory disease that destroys the colon structure. Nevertheless, the exact pathogenesis is not clear and needs to be fully elucidated. MATERIAL AND METHODS Stool and plasma samples were used for 16S ribosomal RNA sequencing and liquid chromatography mass spectrometry, respectively. In addition, we detected the level of trimethylamine N-oxide. Finally, we performed Pearson correlation analysis between the microbiome and the metabolome. ...
Last. Huaben Bo(Guangdong Pharmaceutical University)H-Index: 5
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ETHNOPHARMACOLOGICAL RELEVANCE Danggui Buxue Tang (DBT) is a traditional Chinese medicine, which has the function of supporting Qi and enriching blood. Antibiotics can cause Gut microbiota disorder and affect efficacy of DBT. AIM OF THE STUDY Explore the manner in which Gut microbiota affects the efficacy of Danggui Buxue Tang. MATERIALS AND METHODS In this study, antibiotics were used to destroy gut microbiota. The changes of DBT efficacy were detected to verify the effect of gut microbiota on ...
#1Ye-Ting Zou(Nanjing University of Chinese Medicine)H-Index: 3
#2Jing Zhou(Nanjing University of Chinese Medicine)H-Index: 8
Last. Song-Lin Li(Nanjing University of Chinese Medicine)H-Index: 5
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Abstract Ethnopharmacological relevance Poria cocos (Schw.) Wolf (Poria) is a well-known traditional medicinal fungus. It has been considered to possess spleen-invigorating (Jianpi) effects in traditional Chinese medicine, and is used clinically to treat spleen deficiency (Pixu) with symptoms of intestinal disorders such as diarrhea, indigestion, mucositis and weight loss. The aim of this study To investigate the protective effects of Poria and its three component fractions (Water-soluble polysa...
Bengal slow lorises (Nycticebus bengalensis) are threatened by illegal trade. Subsequently, numerous wild-born individuals are rescued and transferred to rescue centers. Metabonomic analysis of intestinal microbiomes has increasingly played a vital role in evaluating the effects of dietary alteration on the captive status of endangered non-human primates. A synthetic analysis was done to test the differences in gut microbes and fecal metabolites between two dietary groups of Bengal slow lorises ...
