PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells
Abstract
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in biomedical applications. However, the immature state of cardiomyocytes obtained using existing protocols limits the application of hPSC-CMs. Unlike adult cardiac myocytes, hPSC-CMs generate ATP through an immature metabolic pathway-aerobic glycolysis, instead of mitochondrial oxidative phosphorylation (OXPHOS). Hence, metabolic switching is critical for...
Paper Details
Title
PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells
Published Date
Apr 28, 2020
Journal
Volume
12
Issue
8
Pages
7411 - 7430
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