World Journal of Stem Cells

BACKGROUNDPeripheral nerve injury can occur as a result of trauma or disease and carries significant morbidity including sensory and motor loss.The body has limited ability for nerve regeneration and functional recovery.Left untreated, nerve lesions can cause lifelong disability.Traditional treatment options such as neurorrhaphy and neurolysis have high failure rates.Surgical reconstruction with autograft carries donor site morbidity and often provide suboptimal results.Mesenchymal stem cells (MSCs) are known to have promising regenerative potential and have gained attention as a treatment option for nerve lesions.It is however, unclear whether it can be effectively used for nerve regeneration. AIMTo evaluate the evidence for the use of human umbilical cord derived MSCs (UCMSCs) in peripheral nerve regeneration.

Human umbilical cord derived mesenchymal stem cells in peripheral nerve regeneration