World Journal of Stem Cells
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3.23
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450
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#2Brij B. Singh (University of Texas Health Science Center at San Antonio)H-Index: 40
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#1Mathieu Rheault-Henry (Northern Ontario School of Medicine)
#2Ian White (Northern Ontario School of Medicine)
Last. Rony Atoui (Northern Ontario School of Medicine)H-Index: 1
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Heart failure continues to be one of the leading causes of morbidity and mortality worldwide. Myocardial infarction is the primary causative agent of chronic heart failure resulting in cardiomyocyte necrosis and the subsequent formation of fibrotic scar tissue. Current pharmacological and non-pharmacological therapies focus on managing symptoms of heart failure yet remain unable to reverse the underlying pathology. Heart transplantation usually cannot be relied on, as there is a major discrepanc...
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#1Xudong Feng (ZJU: Zhejiang University)H-Index: 3
#2Jiaqi Zhu (ZJU: Zhejiang University)H-Index: 3
Last. Hongcui Cao (ZJU: Zhejiang University)H-Index: 26
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BACKGROUND As human placenta-derived mesenchymal stem cells (hP-MSCs) exist in a physiologically hypoxic microenvironment, various studies have focused on the influence of hypoxia. However, the underlying mechanisms remain to be further explored. AIM The aim was to reveal the possible mechanisms by which hypoxia enhances the proliferation of hP-MSCs. METHODS A hypoxic cell incubator (2.5% O2) was used to mimic a hypoxic microenvironment. Cell counting kit-8 and 5-ethynyl-20-deoxyuridine incorpor...
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Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research
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#2Xuan LuH-Index: 1
Last. Hongcui Cao (ZJU: Zhejiang University)H-Index: 26
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#1Zi-Yi Sun (Ha Tai: Xiamen University)
#2Ting-Yan Yu (Ha Tai: Xiamen University)
Last. Wei Wang (Ha Tai: Xiamen University)
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Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease caused by the specific destruction of pancreatic islet β cells and is characterized as the absolute insufficiency of insulin secretion. Current insulin replacement therapy supplies insulin in a non-physiological way and is associated with devastating complications. Experimental islet transplantation therapy has been proven to restore glucose homeostasis in people with severe T1DM. However, it is restricted by many factors such as se...
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#1Ahmed K. Elsayed (Khalifa University)H-Index: 2
#1Ahmed Kamel Elsayed (Khalifa University)H-Index: 5
Last. Essam M. Abdelalim (Khalifa University)H-Index: 13
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Insulin resistance (IR) is associated with several metabolic disorders, including type 2 diabetes (T2D). The development of IR in insulin target tissues involves genetic and acquired factors. Persons at genetic risk for T2D tend to develop IR several years before glucose intolerance. Several rodent models for both IR and T2D are being used to study the disease pathogenesis; however, these models cannot recapitulate all the aspects of this complex disorder as seen in each individual. Human plurip...
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#1Huasu ZhuH-Index: 1
#2Dong LiH-Index: 11
Last. Xiu-Li Ju
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Top fields of study
Pathology
Mesenchymal stem cell
Immunology
Stem cell
Medicine
Biology
Cell biology