Bone tissue

Fibrillogenesis

Cell biology

Type I collagen

Biology

Biomedical engineering

Materials science

Endocrinology

Extracellular matrix

Biochemistry

Fibril

Collagen, type I, alpha 1

Biomineralization

Mineralized tissues

Paleontology

Matrix (chemical analysis)

Anatomy

Internal medicine

Composite material

Medicine

Chemistry

Dentin

Collagen fibril

Osteopontin

Biophysics

Pathology

Acta Biomaterialia

Osteopontin (OPN) is a non-collagenous protein involved in biomineralization of bone tissue. Beyond its role in biomineralization, we show that osteopontin is essential to the quality of collagen fibrils in bone. Transmission electron microscopy revealed that, in Opn

Osteopontin regulates type I collagen fibril formation in bone tissue