Active ingredient

Biology

Melanin

Skin cancer

Dermatology

Biochemistry

Human skin

Genetics

Internal medicine

Pharmacology

Skin whitening

Medicine

Hyperpigmentation

Cancer

Experimental and Therapeutic Medicine

Melanogenesis is the process for the production of melanin, which is the primary cause of human skin pigmentation. Skin-whitening agents are commercially available for those who wish to have a lighter skin complexions. To date, although numerous natural compounds have been proposed to alleviate hyperpigmentation, insufficient attention has been focused on potential natural skin-whitening agents and their mechanism of action from the perspective of compound classification. In the present article, the synthetic process of melanogenesis and associated core signaling pathways are summarized. An overview of the list of natural skin-lightening agents, along with their compound classifications, is also presented, where their efficacy based on their respective mechanisms of action on melanogenesis is discussed.

Natural skin‑whitening compounds for the treatment of melanogenesis (Review)