Covalent fragment libraries in drug discovery

Volume: 25, Issue: 6, Pages: 983 - 996
Published: Jun 1, 2020
Abstract
Targeted covalent inhibitors and chemical probes have become integral parts of drug discovery approaches. Given the advantages of fragment-based drug discovery, screening electrophilic fragments emerged as a promising alternative to discover and validate novel targets and to generate viable chemical starting points even for targets that are barely tractable. In this review, we present recent principles and considerations in the design of...
Paper Details
Title
Covalent fragment libraries in drug discovery
Published Date
Jun 1, 2020
Volume
25
Issue
6
Pages
983 - 996
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