MRI biomarkers of disease progression and conversion to secondary-progressive multiple sclerosis.

Published on May 3, 2020in Expert Review of Neurotherapeutics3.743
· DOI :10.1080/14737175.2020.1757435
Eleonora Tavazzi22
Estimated H-index: 22
(SUNY: State University of New York System),
Robert Zivadinov83
Estimated H-index: 83
(SUNY: State University of New York System)
+ 4 AuthorsNiels Bergsland40
Estimated H-index: 40
(SUNY: State University of New York System)
Introduction: Conventional imaging measures remain a key clinical tool for the diagnosis multiple sclerosis (MS) and monitoring of patients. However, most measures used in the clinic show unsatisfactory performance in predicting disease progression and conversion to secondary progressive MS.Areas covered: Sophisticated imaging techniques have facilitated the identification of imaging biomarkers associated with disease progression, such as global and regional brain volume measures, and with conversion to secondary progressive MS, such as leptomeningeal contrast enhancement and chronic inflammation. The relevance of emerging imaging approaches partially overcoming intrinsic limitations of traditional techniques is also discussed.Expert opinion: Imaging biomarkers capable of detecting tissue damage early on in the disease, with the potential to be applied in multicenter trials and at an individual level in clinical settings, are strongly needed. Several measures have been proposed, which exploit advanced imaging acquisitions and/or incorporate sophisticated post-processing, can quantify irreversible tissue damage. The progressively wider use of high-strength field MRI and the development of more advanced imaging techniques will help capture the missing pieces of the MS puzzle. The ability to more reliably identify those at risk for disability progression will allow for earlier intervention with the aim to favorably alter the disease course.
📖 Papers frequently viewed together
26 Citations
1 Author (D. L. Arnold)
4 Citations
#1Sara Collorone (UCL: University College London)H-Index: 5
#2N Cawley (UCL: University College London)
Last. Olga Ciccarelli (NIHR: National Institute for Health Research)H-Index: 73
view all 15 authors...
Background:Multiple sclerosis (MS) affects both brain and spinal cord. However, studies of the neuraxis with advanced magnetic resonance imaging (MRI) are rare because of long acquisition times. We...
20 CitationsSource
#1Iris Dekker (VU: VU University Amsterdam)H-Index: 8
#2Madeleine H. Sombekke (VU: VU University Amsterdam)H-Index: 10
Last. Mike P. Wattjes (VU: VU University Amsterdam)H-Index: 60
view all 9 authors...
Objective:The objective of the study was to determine whether early infratentorial and/or spinal cord lesions are long-term cumulative predictors of disability progression in multiple sclerosis (MS...
5 CitationsSource
#1Till SprengerH-Index: 47
#2Ludwig Kappos (University Hospital of Basel)H-Index: 119
Last. Steven CavalierH-Index: 3
view all 8 authors...
Background:Teriflunomide 14 mg significantly reduced brain volume loss (BVL) and confirmed disability worsening (CDW) compared with placebo in the TEMSO core study.Objective:To investigate the rela...
8 CitationsSource
#1Ron Milo (BGU: Ben-Gurion University of the Negev)H-Index: 73
#2Amos D. Korczyn (TAU: Tel Aviv University)H-Index: 72
Last. Olaf Stüve (UTSW: University of Texas Southwestern Medical Center)H-Index: 68
view all 4 authors...
It is currently incompletely understood whether inflammation and neurodegeneration are causally related in multiple sclerosis (MS). The sequence of a potential causal relationship is also unknown. ...
18 CitationsSource
#1Antonella Conte (Sapienza University of Rome)H-Index: 35
#2Costanza Giannì (Sapienza University of Rome)H-Index: 16
Last. Patrizia Pantano (Sapienza University of Rome)H-Index: 57
view all 10 authors...
Background:Somatosensory temporal discrimination threshold (STDT) is altered in multiple sclerosis (MS). In healthy subjects (HS), voluntary movement modulates the STDT through mechanisms of subcortical sensory gating.Objective:With neurophysiological and magnetic resonance imaging (MRI) techniques, we investigated sensory gating and sensorimotor integration in MS.Methods:We recruited 38 relapsing-remitting multiple sclerosis (RR-MS) patients with no-to-mild disability and 33 HS. We tested STDT ...
6 CitationsSource
#1Bao Ying Chen (UCLA: University of California, Los Angeles)H-Index: 4
#2Chiara Ghezzi (UCLA: University of California, Los Angeles)H-Index: 14
Last. Peter M. Clark (UCLA: University of California, Los Angeles)H-Index: 14
view all 7 authors...
Brain-infiltrating leukocytes contribute to multiple sclerosis (MS) and autoimmune encephalomyelitis and likely play a role in traumatic brain injury, seizure, and stroke. Brain-infiltrating leukocytes are also primary targets for MS disease-modifying therapies. However, no method exists for non-invasively visualizing these cells in a living organism. 1-(2'-deoxy-2'-18F-fluoroarabinofuranosyl) cytosine (18F-FAC) is a PET radiotracer that measures deoxynucleoside salvage and accumulates preferent...
4 CitationsSource
#1Eleonora Tavazzi (SUNY: State University of New York System)H-Index: 22
#2Niels Bergsland (SUNY: State University of New York System)H-Index: 40
Last. Robert Zivadinov (SUNY: State University of New York System)H-Index: 83
view all 14 authors...
Background Atrophied T2-lesion volume (LV) is a novel MRI marker representing brain-lesion loss due to atrophy, able to predict long-term disability progression and conversion to secondary-progressive multiple sclerosis (MS).
5 CitationsSource
#1Sylvain Auvity (Université Paris-Saclay)H-Index: 9
#2Matteo Tonietto (University of Paris)H-Index: 10
Last. Bruno Stankoff (University of Paris)H-Index: 25
view all 8 authors...
Purpose Drugs promoting myelin repair represent a promising therapeutic approach in multiple sclerosis and several candidate molecules are currently being evaluated, fostering the need of a quantitative method to specifically measure myelin content in vivo. PET using the benzothiazole derivative 11C-PiB has been successfully used to quantify myelin content changes in humans. Stilbene derivatives, such as 11C-MeDAS, have also been shown to bind to myelin in animals and are considered a promising ...
13 CitationsSource
#1Antonio Carotenuto ('KCL': King's College London)H-Index: 15
#2Beniamino Giordano ('KCL': King's College London)H-Index: 4
Last. Marios Politis ('KCL': King's College London)H-Index: 46
view all 15 authors...
Purpose We evaluated myelin changes throughout the central nervous system in Multiple Sclerosis (MS) patients by using hybrid [18F]florbetapir PET-MR imaging.
5 CitationsSource
#1Tjalf Ziemssen (TUD: Dresden University of Technology)H-Index: 53
#2Katja Akgün (TUD: Dresden University of Technology)H-Index: 10
Last. Wolfgang Brück (GAU: University of Göttingen)H-Index: 99
view all 3 authors...
Multiple sclerosis (MS) is an inflammatory-neurodegenerative disease of the central nervous system presenting with significant inter- and intraindividual heterogeneity. However, the application of clinical and imaging biomarkers is currently not able to allow individual characterization and prediction. Complementary, molecular biomarkers which are easily quantifiable come from the areas of immunology and neurobiology due to the causal pathomechanisms and can excellently complement other disease ...
51 CitationsSource
Cited By4
#1Eleonora Tavazzi (SUNY: State University of New York System)H-Index: 22
#2Marta CazzoliH-Index: 1
Last. Francesca BaglioH-Index: 23
view all 7 authors...
Background: Motor rehabilitation is routinely used in clinical practice as an effective method to reduce progressive disability gain in multiple sclerosis (MS), but rehabilitation approaches are typically unstandardized, and only few studies have investigated the impact of rehabilitation on brain neuroplasticity. Objective: To summarize and critically analyze studies applying MRI markers of functional connectivity and structural changes to assess the effect of motor rehabilitation on brain neuro...
#1Mahdi Barzegar (IUMS: Isfahan University of Medical Sciences)H-Index: 6
#2Soroush Najdaghi (IUMS: Isfahan University of Medical Sciences)
Last. Vahid Shaygannejad (IUMS: Isfahan University of Medical Sciences)H-Index: 23
view all 6 authors...
BACKGROUND We conducted this study to estimated the time of conversion from relapsing-remitting MS (RRMS) to SPMS and its early predictor factors. METHODS In this retrospective study, demographic, clinical, and imaging data from MS patients at diagnosis were extracted. Cox proportional hazards model was used to assess the association between various baseline characteristics and conversion to SPMS. We also assessed the association brtween escalation and early intensive therapy approaches with tra...
#1B. Cree (UCSF: University of California, San Francisco)H-Index: 3
#2Douglas L. ArnoldH-Index: 111
Last. Hans Lassmann (Medical University of Vienna)H-Index: 172
view all 8 authors...
In most cases, multiple sclerosis (MS) begins with a relapsing-remitting course followed by insidious disability worsening that is independent from clinically apparent relapses and is termed secondary progressive multiple sclerosis (SMPS). Major differences exist between relapsing-remitting MS (RRMS) and SPMS, especially regarding therapeutic response to treatment. This review provides an overview of the pathology, differentiation, and challenges in the diagnosis and treatment of SPMS. We emphas...
1 CitationsSource