Enteroendocrine cell

Internal medicine

Receptor

Pancreas

Colorectal cancer

Carcinogenesis

Biology

Cancer

Endocrinology

Islet

Tumor progression

Insulin

Cholecystokinin

Pancreatic cancer

Adenocarcinoma

KRAS

Endocrine system

Cancer research

Genetics

Hormone

Medicine

Cell

Obesity is an intrinsic driver of PDAC in mice, leading to a remodeling of beta cells to increase CCK secretion and playing a role early in pancreatic cancer development that can be intercepted by weight loss.

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma