Psychological repression

Transcription factor

Biology

Promoter

Gene

Gene expression

Philosophy

STAT protein

Transcription (linguistics)

Molecular biology

Incubation

Chemistry

STAT3

Linguistics

Regulator

Cell biology

Epigenetics

Genetics

Biochemistry

Science

How egg temperature sets sex In many reptiles, sex is determined by nest temperature during egg incubation. Temperature regulates the expression of an epigenetic modifier gene called Kdm6b , which is responsible for testis development. However, the molecular connection between temperature and sex-specific expression of this factor was previously unknown. Weber et al. have identified a link between temperature and the activation of a key regulator of Kdm6b called signal transducer and activator of transcription 3 (STAT3). After an influx of Ca 2+ at the warmer, female-producing temperature, STAT3 is phosphorylated and silences Kdm6b transcription to repress testis development. Science , this issue p. 303

Temperature-dependent sex determination is mediated by pSTAT3 repression of <i>Kdm6b</i>

Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b