PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression
Abstract
The proto-oncogene c-Myc regulates multiple biological processes mainly through selectively activating gene expression. However, the mechanisms underlying c-Myc-mediated gene repression in the context of cancer remain less clear. This study aimed to clarify the role of PRMT5 in the transcriptional repression of c-Myc target genes in gastric cancer. Methods: Immunohistochemistry was used to evaluate the expression of PRMT5, c-Myc and target genes...
Paper Details
Title
PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression
Published Date
Jan 1, 2020
Journal
Volume
10
Issue
10
Pages
4437 - 4452
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