Anti‐Inflammatory and Antioxidative Properties of Isoflavones Provide Renal Protective Effects Distinct from Those of Dietary Soy Proteins against Diabetic Nephropathy

Scope Dietary soy reportedly protects from diabetic nephropathy (DN), but its active components and mechanism of action remain unknown. Methods and results In this study, KKAy mice are fed three types of diet: Dietary soy isoflavones with soy protein (Soy‐IP) diet, reduced isoflavones soy protein (RisoP), and oral administration of isoflavones aglycones (IsoAgc). Albuminuria and glycosuria are decreased only in the soy‐IP group. The risoP group...