Original paper
Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
Abstract
In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR-34a), was determined and evaluated in patients with advanced solid tumours.Adults with various solid tumours refractory to standard treatments were enrolled in 3 + 3 dose-escalation cohorts and, following RP2D determination, expansion cohorts. MRX34, with oral dexamethasone premedication,...
Paper Details
Title
Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
Published Date
Apr 2, 2020
Journal
Volume
122
Issue
11
Pages
1630 - 1637
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Notes
History