Pathology

Erythema

Disease

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Dermatology

Hydroxychloroquine

Drug eruption

Drug

Acute generalized exanthematous pustulosis

Medicine

Pharmacology

Dermatologic Therapy

A severe cutaneous drug reaction resembling acute generalized exanthematous pustulosis resulting from ingestion of hydroxychloroquine has been documented. It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. Given the anticipated surge in the use of hydroxychloroquine due to its reported benefits in those with coronavirus disease 2019, specific recognition of this entity is pivotal. We delineate it as generalized pustular figurate erythema.

Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine