model hiv

antiretroviral therapy

hiv medicine

antiretroviral drugs

immune reconstitution

viral load

hiv infected

hiv dna

infected individuals

Cell

Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of antiretroviral therapy (ART). To remove the stigma and burden of chronic infection, approaches to eradicate or cure HIV infection are desired. Attempts to augment ART with therapies that reverse viral latency, paired with immunotherapies to clear infection, have advanced into the clinic, but the field is still in its infancy. We review foundational studies and highlight new insights in HIV cure research. Together with advances in ART delivery and HIV prevention strategies, future therapies that clear HIV infection may relieve society of the affliction of the HIV pandemic. Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of antiretroviral therapy (ART). To remove the stigma and burden of chronic infection, approaches to eradicate or cure HIV infection are desired. Attempts to augment ART with therapies that reverse viral latency, paired with immunotherapies to clear infection, have advanced into the clinic, but the field is still in its infancy. We review foundational studies and highlight new insights in HIV cure research. Together with advances in ART delivery and HIV prevention strategies, future therapies that clear HIV infection may relieve society of the affliction of the HIV pandemic. Human immunodeficiency virus type 1 (HIV-1) has led to nearly 50 million deaths and inflicted suffering across the globe. As this pandemic emerged, a remarkable response of clinicians, researchers, social activists, the pharmaceutical industry, and public authorities resulted in the development and implementation of potent antiretroviral therapy (ART), able to arrest disease, restore health, and reduce the spread of new infection. Developments in ART continue, with long-acting antivirals and engineered antibodies in advanced clinical trials that offer the promise of replacing daily pills for treatment and prevention with only a few treatments per year (Gulick and Flexner, 2019Gulick R.M. Flexner C. Long-Acting HIV Drugs ...

Curing HIV: Seeking to Target and Clear Persistent Infection