Finite Element Simulation of Ionic Electrodiffusion in Cellular Geometries

Mathematical models for excitable cells are commonly based on cable theory, which considers a homogenized domain and spatially constant ionic concentrations. Although such models provide valuable insight, the effect of altered ion concentrations or detailed cell morphology on the electrical potentials cannot be captured. In this paper, we discuss an alternative approach to detailed modelling of electrodiffusion in neural tissue. The mathematical...