Gene

NF-κB

Programmed cell death

Cell biology

Biology

Regulator

Apoptosis

Autophagy

Signal transduction

Cancer research

NFKB1

Genetics

RIPK1

Transcription factor

Necroptosis

Cancer

Cancer cell

Cell Death and Disease

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.

Life, death, and autophagy in cancer: NF-κB turns up everywhere