Anatomy

Evolutionary biology

Biology

Gene

Computational biology

Cell biology

Chromosome

Genetics

Ultrastructure

Molecular Cell

Krietenstein et al. extend analyses of chromosome folding to nucleosome resolution in human cells. These ultra-deep Micro-C maps capture known features of chromosomes with improved signal-to-noise, identifying tens of thousands of new looping interactions. Newly identified loops reveal weak pause sites along cohesin extrusion tracks, providing insight into TAD structural heterogeneity.

Ultrastructural Details of Mammalian Chromosome Architecture