Abstract The solid-liquid phase equilibrium solubility of Doxofylline was measured and discussed in ten pure organic solvents and co-solvent mixtures of acetonitrile + ethanol (+or water) at temperature range from 278.15 to 323.15 K. Results indicated that experimental mole fraction (x) of Doxofylline in ten neat solvents followed this order: acetonitrile > tetrahydrofuran > benzene > acetone > ethyl acetate > methanol > 1-propanol ≈ 2-propanol > ethanol ≈ water, and solubility increased with temperature increasing. Moreover, experimental solubility of Doxofylline firstly increased and then declined with the mass fraction increasing of acetonitrile in acetonitrile + ethanol (+or water) mixture solvents at each temperature. Hansen solubility parameter and solvent effect were used for explaining and discussing solubility rule of Doxofylline in selected solvents. Model correlation indicated the NRTL model was the most suitable than other models to predict solubility of Doxofylline in pure solvents and Sun model was better than other models in mixture solvents with accompanied by temperature and composition. Furthermore, thermodynamic properties of standard molar enthalpy, molar Gibbs free energy and molar entropy in solution was calculated and discussed.
Last. Baozeng Ren(Zhengzhou University)H-Index: 19
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Abstract Mole-fraction solubility of 5-norbornene-2,3-dicarboximide (NODI) in eleven solvents including methanol (MtOH), ethanol (EtOH), 2-ethoxyethanol, methyl acetate (MAC), ethyl acetate (EAC), n-propyl acetate (NPAC), isopropyl acetate (IPAC), n-butyl acetate (NBAC), acetone (DMK), N,N-dimethylformamide (DMF) at (278.15–323.15) K and 1,4-dioxane at (288.15–323.15) K was experimentally measured by laser monitoring technique under 0.1 MPa. Solubility of NODI increased with the increasing tempe...
#1Homa Rezaei(Tabriz University of Medical Sciences)H-Index: 3
#2Elaheh Rahimpour(Tabriz University of Medical Sciences)H-Index: 13
Last. Abolghasem Jouyban(Tehran University of Medical Sciences)H-Index: 54
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Abstract The solubility of caffeine in non-aqueous mixed solutions of carbitol and ethanol at different temperatures are determined by a shake-flask method and fitted to some reported cosolvency models including the van't Hoff, the double log-log, the mixture response surface, the Yalkowsky, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, and the modified Wilson models. Along with solubility, the densities of caffeine saturated mixtures are also measured and correlated with the Jouyban-Acree mo...
#1Homa Rezaei(Tabriz University of Medical Sciences)H-Index: 3
#2Elaheh Rahimpour(Tabriz University of Medical Sciences)H-Index: 13
Last. Abolghasem Jouyban(Tehran University of Medical Sciences)H-Index: 54
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Abstract The solubility profile of caffeine in the binary non-aqueous mixtures of N-methyl-2-pyrrolidone (NMP) and ethanol at different temperatures is determined and the obtained data are fitted to some linear and non-linear cosolvency models including the van't Hoff, the double log-log, the mixture response surface, Yalkowsky, Jouyban-Acree, Jouyban-Acree-van't Hoff, and the modified Wilson models. The measured density data of caffeine saturated solutions as another physico-chemical property a...
#1Yanmin Shen(Henan University of Technology)H-Index: 2
#2Wenju Liu(Henan University of Technology)H-Index: 2
Last. Zehua Bao(Henan University of Technology)H-Index: 2
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Abstract The solubility values of Doxycycline Hyclate (DH) in water + methanol (or +ethanol and n-propanol) mixture solvents were measured and correlated from 276.95 K to 323.75 K. Experiment results indicated that solubility data in four pure solvents followed this order: methanol> ethanol≈water>n-propanol, and solubility data increased with increasing temperature in all selected solvents. In mixture solvents, the solubility data of Doxycycline Hyclate reached a minimum at xc = 0.75 in water(xc...
Last. Saeid Faraji(University of Tabriz)H-Index: 6
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Abstract Due to very low solubility of indomethacin (IMC) in water, the solubility of IMC was measured in full ranges concentrations w3 = (0.0, 0.2, 0.4, 0.6, 0.8, 0.9, and 1.0) of 1-ethyl-3-methylimidazolium ethyl sulfate [EMIM][ES] ionic liquid (IL) in aqueous solutions at several temperatures T = (293.15 K to 318.15 K). The results indicate that the solubility of IMC is increased by increasing the concentration of [EMIM][ES] and temperature. The solubility of IMC in [EMIM][ES] was raised 30,0...
Last. Jiajia Yin(Xi'an Jiaotong University)H-Index: 1
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Recently, the Eyring-modified two-suffix-margules (MTSM) model for calculating viscosities of ionic liquid mixtures was proposed by Atashrouz et al. (Atashrouz, S.; Zarghampour, M.; Abdolrahimi, S.; Pazuki, G.; Nasernejad, B. J. Chem. Eng. Data 2014, 59, 3691–3704). In this work, a simple modification of the Eyring-MTSM model was presented and applied to the viscosity calculation of binary mixtures of organic solvents. The accuracy of the modified model was assessed by comparing experimental vis...
Last. William E. Acree(UNT: University of North Texas)H-Index: 75
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ABSTRACTThe experimental data reported in the paper by Cai and co-workers [DOI: 10.1080/00319104.2016.1163560] pertaining to the solubility of myricetin dissolved in binary aqueous–ethanol solvent mixtures has been reanalysed. A correct mathematical derivation is provided for the correlation expression from a combination of the van’t Hoff and Jouyban–Acree models. Cai et al. who used the expression in their study, however, erroneously implied that the expression resulted from a simple transforma...
The interactions of amino acids + water + 1-ethyl-3-methylimidazolium chloride [emim][Cl] solutions have been studied at different temperatures using volumetric and acoustic measurements. The density (ρ) and speed of sound (u) of glycine/l-alanine/l-valine + water + 1-ethyl-3-methylimidazolium chloride solutions have been measured at temperatures T = (288.15, 293.15, 298.15, 303.15, and 308.15) K and experimental pressure of 0.1 MPa. The apparent molar properties, standard partial molar properti...
Last. Baozeng Ren(Zhengzhou University)H-Index: 19
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Abstract The solubility data of tylosin tartrate in methanol + (tetrahydrofuran or acetone) mixtures was determined at atmospheric pressure by a gravimetric method over temperature range of 293.15–323.15 K. The experimental results indicated that solubility of tylosin tartrate increases with increasing temperature in selected solvents, and that solubility of tylosin tartrate first increases, reaches a maximum and then decreases with increasing the mass fraction of methanol in the binary solvent ...
Last. Yonghong Hu(Nanjing Tech University)H-Index: 18
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Abstract The work of this article is to measure the solubility of 6-Chloro-7-azapurine in twelve single solvents (methanol, ethanol, isopropanol, n-propanol, n-butanol, tetrahydrofuran, acetone, ethyl acetate, acetonitrile, n-hexane, n-heptane, toluene) and four binary mixed solvent systems (Tetrahydrofuran + ethyl acetate) (Tetrahydrofuran + isopropanol) (Tetrahydrofuran + acetonitrile) (Tetrahydrofuran + methanol) at different temperatures (283.15–303.15 K) under atmospheric pressure. Accordin...
Abstract null null The solubility of 3-nitropyrazole in four binary solvents (water + methanol, ethanol, 1-propanol and acetone) was measured by a dynamic laser monitoring over the temperature range of 283.15 K, 288.15 K, 293.15 K, 298.15 K, 303.15 K, 308.15 K, 313.15 K, 318.15 K and 323.15 K at pressure of 0.1 MPa. The solubility of 3-nitropyrazole increased positively with increasing temperature, while increased with decreasing mass-fraction of water in each binary system. Moreover, the experi...
Abstract Despite extensive literature regarding the effect of solvent on numerous physicochemical processes, the solvent effect on the adsorption kinetics of a surface-active compound is yet to be explored. This study first investigated the adsorption kinetics of dibutyl phthalate (DBP) in 1 wt% aqueous methanol (MeOH) solvent: dynamic and equilibrium surface tension (ST) data were measured using a pendant bubble tensiometer and the resultant ST data were examined via theoretical simulation. The...
Last. Baozeng Ren(Zhengzhou University)H-Index: 19
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Abstract By means of the laser dynamic method, the saturation solubility of benflumetol (BFL) in four binary mixtures ((ethyl acetate (EAC), n-propyl acetate (NPAC), n-butyl acetate (NBAC) and n-amyl acetate (NAAC)) + methanol (MtOH)) was achieved at temperatures from 278.15 K to 323.15 K and ambient pressure (p = 0.1 MPa). The solubility values (mole fraction) of BFL in above four binary mixed solvents increased as temperature elevated and obeyed the decreasing tendency with the decrease of the...
Last. Ling Zhou(TJU: Tianjin University)H-Index: 5
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Abstract null null Researches on the basic solubility data and the physicochemical parameters of isovanillin are scarce in literature. In this paper, the solubility data, dissolution thermodynamic properties of isovanillin in 15 organic pure solvents (methanol, ethanol, n-propanol, iso-propanol, n-butanol, iso-butanol, methyl acetate, ethyl acetate, isobutyl acetate, formic acid, acetic acid, propionic acid, acetone, xylene and diethyl ether) and 4 binary solvents (ethanol + water, iso-propanol ...
Last. Yonghong Hu(Nanjing Tech University)H-Index: 18
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Abstract null null In the research, the solubility of curcumin was studied by static equilibrium method combined with HPLC. The solubility data of curcumin was measured in twelve pure solvents (dimethyl sulfoxide, tetrahydrofuran, acetone, ethyl acetate, isopropanol, acetonitrile, 1-butanol, ethanol, methanol, xylenes, n-hexane and n-heptane) and three binary solvent mixtures (acetone + tetrahydrofuran, acetonitrile + tetrahydrofuran and n-hexane + tetrahydrofuran) at different temperature (T = ...
#1Tingting Liu(Huada: Beijing University of Chemical Technology)
#2Shui Wang(Huada: Beijing University of Chemical Technology)H-Index: 11
Last. Zhong Zhao(Huada: Beijing University of Chemical Technology)
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Doxofylline (DFL) is a theophylline derivative with poor solubility in water. In this paper, the solubility of DFL (as mole fraction) in 17 organic solvents including 4 esters (ethyl acetate, n-pro...
Last. Baozeng Ren(Zhengzhou University)H-Index: 19
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Abstract The equilibrium solubility and thermodynamic properties of busulfan in fifteen organic single solvents were reported. Solubility determinations were performed through the laser monitoring method at T = (278.15-323.15) K (except DMSO at 298.15-323.15 K) and p = 101.3 kPa. It can be found that the mole fraction solubility of busulfan increases apparently with the augmented experimental temperature. The solubility of busulfan in single solvents exhibits the following order from maximum to ...
Abstract The solubility of Progesterone at T = 278.15–323.15 K was measured by static equilibrium method combined with HPLC in twelve solvents (methanol, ethanol, isopropanol, n-propanol, n-butanol, acetone, tetrahydrofuran, 1,4-dioxane, n-heptane, ethyl acetate, acetonitrile, and toluene) and three binary solvents (tetrahydrofuran + n-heptane, 1,4-dioxane + n-heptane, and toluene + n-heptane). The results showed that progesterone has the highest solubility in toluene (0.2249 in mole fraction) a...
Abstract The equilibrium solubility and thermodynamic properties of benorilate in six pure solvents (methyl acetate, n-propyl acetate, n-butyl acetate, n-pentyl acetate, DMAC and DMSO) and two binary solvents (DMAC + n-pentyl acetate, DMSO + n-pentyl acetate) were reported. Solubility determinations were performed through the laser monitoring method at T = (278.15–323.15) K and p = 0.1 MPa, except DMSO at (293.15–323.15) K. The measurement results illustrated that the solubility of benorilate in...