Biochemistry, Substance P

Substance P is a neuropeptide made up of 11 amino acids—an undecapeptide—and is a part of the tachykinin neuropeptide family. Its receptor, neurokinin type 1 (NK-1R), is a transmembrane bound receptor on many cell types in the body including the endothelium of the blood vessels and lymphatics, white blood cells (WBCs), fibroblasts and neurons. Substance P's most well-known function is as a neurotransmitter and a modulator of pain perception by...