Physicochemical characterization and molecular modeling study of host–guest systems of aripiprazole and functionalized cyclodextrins

Aripiprazole (ARP), an innovative atypical antipsychotic drug, exhibits very low aqueous solubility, affecting its dissolution and absorption and high lipophilicity. Its complexation with cyclodextrins (CDs) was designed to improve drug solubility and consequently its bioavailability. The inclusion complexes of aripiprazole with two β-cyclodextrin derivative, namely random methyl-β-cyclodextrin (RAMEB) and...