Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy

Volume: 12, Issue: 534
Published: Mar 11, 2020
Abstract
PD-L1/PD-1 blocking antibodies have demonstrated therapeutic efficacy across a range of human cancers. Extending this benefit to a greater number of patients, however, will require a better understanding of how these therapies instigate anticancer immunity. Although the PD-L1/PD-1 axis is typically associated with T cell function, we demonstrate here that dendritic cells (DCs) are an important target of PD-L1 blocking antibody. PD-L1 binds two...
Paper Details
Title
Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy
Published Date
Mar 11, 2020
Volume
12
Issue
534
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