Autonomic nervous system and inflammation interaction in endometriosis-associated pain

Published on Mar 7, 2020in Journal of Neuroinflammation5.793
· DOI :10.1186/S12974-020-01752-1
Yajing Wei1
Estimated H-index: 1
(SYSU: Sun Yat-sen University),
Yanchun Liang10
Estimated H-index: 10
(SYSU: Sun Yat-sen University)
+ 2 AuthorsShuzhong Yao6
Estimated H-index: 6
(SYSU: Sun Yat-sen University)
Sources
Abstract
Endometriosis is a chronic inflammatory disease. Pain is the most common symptom in endometriosis. Endometriosis-associated pain is caused by inflammation, and is related to aberrant innervation. Although the specific mechanism between endometriosis-associated pain and the interaction of aberrant innervation and inflammation remains unclear, many studies have confirmed certain correlations between them. In addition, we found that some chronic inflammatory autoimmune diseases (AIDs) such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) share similar characteristics: the changes in dysregulation of inflammatory factors as well as the function and innervation of the autonomic nervous system (ANS). The mechanisms underlying the interaction between the ANS and inflammation have provided new advances among these disorders. Therefore, the purpose of this review is to compare the changes in inflammation and ANS in endometriosis, IBD, and RA; and to explore the role and possible mechanism of sympathetic and parasympathetic nerves in endometriosis-associated inflammation by referring to IBD and RA studies to provide some reference for further endometriosis research and treatment.
📖 Papers frequently viewed together
2019
7 Authors (Dora Pavone, ..., Felice Petraglia)
1 Citations
2018
1 Author (Kathryn Vaubel)
2010
References166
Newest
#1Upendra Kumar Soni (Central Drug Research Institute)H-Index: 4
#2Sangappa Basanna Chadchan (Central Drug Research Institute)H-Index: 4
Last. Rajesh Kumar Jha (Central Drug Research Institute)H-Index: 15
view all 11 authors...
: Endometriosis is a prevalent gynecological disorder that eventually gives rise to painful invasive lesions. Increased levels of transforming growth factor-beta 1 (TGF-B1) have been reported in endometriosis. However, details of the effects of high TGF-B1 on downstream signaling in ectopic endometrial tissue remain obscure. We induced endometriotic lesions in mice by surgical auto-transplantation of endometrial tissues to the peritoneal regions. We then treated endometriotic (ectopic and eutopi...
14 CitationsSource
#1Yanchun Liang (SYSU: Sun Yat-sen University)H-Index: 10
#2Jinjie Wu (SYSU: Sun Yat-sen University)H-Index: 3
Last. Shuzhong Yao (SYSU: Sun Yat-sen University)H-Index: 16
view all 5 authors...
Abstract Endometriosis is a complex and heterogeneous disorder of unknown aetiology. This benign disease possesses special biological behaviours that mimic those of malignant tumours. A pro-endometriotic niche established by an existing lesion is a supportive micro-environment for the progression of endometriosis. After the accumulation of cells by an existing lesion, these components display distinct characteristics that impair immune surveillance. Subsequent retrograde menstruation of endometr...
9 CitationsSource
#1Yanling Gou (HMU: Harbin Medical University)H-Index: 2
#2Xue Li (HMU: Harbin Medical University)H-Index: 1
Last. Zongfeng Zhang (HMU: Harbin Medical University)H-Index: 5
view all 10 authors...
STUDY QUESTION: How is the activation of estrogen receptor β (ERβ) in endometriotic stromal cells (ESCs) involved in macrophage recruitment to promote the pathogenesis of endometriosis? SUMMARY ANSWER: ERβ modulates the production of C-C motif chemokine ligand 2 (CCL2) via nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling in ESCs and thus recruits macrophages to ectopic lesions to promote pathogenesis. WHAT IS KNOWN ALREADY: Macrophages are mainly recruited to the ...
17 CitationsSource
#1Hsun-Ming Chang (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 25
#2Hai-Cui Wu (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 1
Last. Peter C.K. Leung (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 76
view all 5 authors...
BACKGROUND: Neurotrophins [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] and glial cell line-derived neurotrophic factor (GDNF) are soluble polypeptide growth factors that are widely recognized for their roles in promoting cell growth, survival and differentiation in several classes of neurons. Outside the nervous system, neurotrophin (NT) and GDNF signaling events have substantial roles in various non-neural tissues, inclu...
26 CitationsSource
#1Yaoming Peng (ZJU: Zhejiang University)H-Index: 2
#2Junyan MaH-Index: 8
Last. Jun Lin (ZJU: Zhejiang University)H-Index: 16
view all 3 authors...
The activation of systemic and local inflammatory mechanisms, including elevated levels of chemokines and proinflammatory cytokines in endometriosis progression, is becoming more evident in the recent years. Here, we report the involvement of CXC chemokine 16 (CXCL16) and its sole receptor, CXC chemokine receptor 6 (CXCR6), in pathophysiology of endometriosis. Expression of CXCL16, but not CXCR6, was significantly upregulated in endometriotic lesions when compared to control endometrium. Additio...
12 CitationsSource
#1Ana-Maria DullH-Index: 2
#2Marius MogaH-Index: 12
Last. Costin Vlad AnastasiuH-Index: 5
view all 6 authors...
Endometriosis represents a severe gynecological pathology, defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathology affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Despite long periods of studies and investigations, the etiology and pathogenesis of this disease still remain not fully unders...
30 CitationsSource
#1Chengcan Yao (Edin.: University of Edinburgh)H-Index: 13
#2Shuh Narumiya (Kyoto University)H-Index: 149
: Chronic inflammation underlies various debilitating disorders including autoimmune, neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant activation of the innate and acquired immune systems is frequently seen. Since non-steroidal anti-inflammatory drugs exert their effects by inhibiting COX and suppressing PG biosynthesis, PGs have been traditionally thought to function mostly as mediators of acute inflammation. However, an inducible COX isoform, COX-2, is often...
44 CitationsSource
#1Stefan Bäurle (Bayer)H-Index: 1
#2Jens Nagel (Bayer)H-Index: 14
Last. Gernot Langer (Bayer)H-Index: 1
view all 15 authors...
The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients are primarily driven by hormone-dependent and inflammatory processes—the latter being frequently associated with severe, acute, and chronic pelvic pain. The EP4 subtype of prostaglandin E2 (PGE2) receptors (EP4-R) is a particularly promising anti-inflammatory and antinociceptive target as both this receptor subtype and the pathways forming PGE2 are highly expressed in endometriotic lesions. High-th...
8 CitationsSource
#1Nikola Sekulovski (Southern Illinois University School of Medicine)H-Index: 5
#2Allison E Whorton (Southern Illinois University School of Medicine)H-Index: 4
Last. Kanako Hayashi (Southern Illinois University School of Medicine)H-Index: 27
view all 5 authors...
Endometriosis causes severe chronic pelvic pain and infertility. We have recently reported that niclosamide treatment reduces growth and progression of endometriosis-like lesions and inflammatory signaling (NFKB and STAT3) in a mouse model. In the present study, we examined further inhibitory mechanisms by which niclosamide affects endometriotic lesions using an endometriotic epithelial cell line, 12Z, and macrophages differentiated from a monocytic THP-1 cell line. Niclosamide dose dependently ...
8 CitationsSource
#1Rose Willemze (UvA: University of Amsterdam)H-Index: 7
#1R.A. Willemze (UvA: University of Amsterdam)H-Index: 2
Last. Wouter J. de Jonge (UvA: University of Amsterdam)H-Index: 30
view all 15 authors...
Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to investigate the role of sympathetic innervation to the intestine on regulation of the innate immune responses. In lipopolysaccharide (LPS)-stimulated macrophages, we evaluated the effect of adrenergic receptor activation on cytokine production and metabolic profile. In vivo, the effect of sympath...
16 CitationsSource
Cited By3
Newest
#1Philippa T. K. Saunders (Edin.: University of Edinburgh)H-Index: 89
#2Andrew W Horne (Edin.: University of Edinburgh)H-Index: 39
Summary Endometriosis is a common condition associated with infertility that causes chronic pain in many, but not all, women. It is defined by the presence of endometrial-like tissue outside the uterus. Although the cause and natural history of the disorder remain uncertain, hormonal, neurological, and immunological factors are all implicated in the mechanisms contributing to development of symptoms. Because definitive diagnosis requires surgery, there is often a long diagnostic delay after onse...
2 CitationsSource
Endometriosis and cancer have much in common, notably their burgeoning of cells in hypoxic milieus, their invasiveness, and their capacity to trigger remodeling, vascularization, and innervation of other tissues. An important role in these processes is played by permissive microenvironments inhabited by a variety of stromal and immune cells, including macrophages. Remarkable phenotypical plasticity of macrophages makes them a promising therapeutic target; some key issues are the range of macroph...
Source
#2Nicolette Halben (Charité)
Last. Sylvia Mechsner (Charité)H-Index: 22
view all 7 authors...
Abstract Research Question What is the potential role of immune cells and their inflammatory cytokines in the pathogenesis, development and establishment of endometriosis (EM)? Design Peritoneal fluid (PF) from 59 women (43 patients with EM and 16 controls) who had undergone laparoscopic surgery were analyzed. Changes in innate and adaptive immune cells population, as well as, cytokines, chemokines, and growth factors expression were measured by flow cytometry, Luminex Technology and ELISA. Resu...
Source