Organic chemistry

Intensive care medicine

Chemistry

Ketene

Medicine

Proceedings of the National Academy of Sciences

Significance The Centers for Disease Control and Prevention has recently reported an increasing number of clinically cases of lung injury following use of vaping products. The cause(s) of this growing epidemic of vaping-associated pulmonary injury remain unidentified, although vitamin E acetate has been identified as one possible causative agent. In this research, a combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in lung injuries associated with vaping products. Our important results will help inform medical practitioners, research scientists, and the public, which may assist in bringing this medical crisis under control.

Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate