Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity

Neuroplasticity forms the basis for neuronal circuit complexity and differences between otherwise similar circuits. We show that the microphthalmia-associated transcription factor ( Mitf ) plays a central role in intrinsic plasticity of olfactory bulb (OB) projection neurons. Mitral and tufted (M/T) neurons from Mitf mutant mice are hyperexcitable, have a reduced A-type potassium current (I A ) and exhibit reduced expression of Kcnd3 , which...