Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity
Abstract
Neuroplasticity forms the basis for neuronal circuit complexity and differences between otherwise similar circuits. We show that the microphthalmia-associated transcription factor (Mitf) plays a central role in intrinsic plasticity of olfactory bulb (OB) projection neurons. Mitral and tufted (M/T) neurons from Mitf mutant mice are hyperexcitable, have a reduced A-type potassium current (IA) and exhibit reduced expression of Kcnd3, which encodes...
Paper Details
Title
Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity
Published Date
Mar 1, 2020
Journal
Volume
7
Issue
2
Pages
ENEURO.0412 - 19.2020
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