DESign of Sustainable One-Pot Chemoenzymatic Organic Transformations in Deep Eutectic Solvents for the Synthesis of 1,2- Disubstituted Aromatic Olefins

Published on Mar 6, 2020in Frontiers in chemistry3.693
· DOI :10.3389/FCHEM.2020.00139
Nicolás Ríos-Lombardía17
Estimated H-index: 17
,
María J. Rodríguez-Álvarez9
Estimated H-index: 9
(University of Oviedo)
+ 5 AuthorsJoaquín García-Álvarez10
Estimated H-index: 10
(University of Oviedo)
Sources
Abstract
The self-assembly of styrene-type olefins into the corresponding stilbenes was conveniently performed in the Deep Eutectic Solvent (DES) mixture 1ChCl/2Gly under air and in the absence of hazardous organic co-solvents using a one-pot chemo-biocatalytic route. Here, an enzymatic decarboxylation of p-hydroxycinnamic acids sequentially followed by a ruthenium-catalyzed metathesis of olefins has been investigated in DES solvent. Moreover, and to extend the design of chemoenzymatic processes in DESs, we also coupled the aforementioned enzymatic decarboxylation reaction to now concomitant Pd-catalyzed Heck-type C-C coupling to produce biaryl derivatives under environmentally friendly reaction conditions.
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This work was supported by the University of Alicante (VIGROB-316) and the Spanish Ministerio de Economia, Industria y Competitividad (CTQ2015-66624-P, PGC2018-096616-B-100). BS thanks Generalitat Valenciana (ACIF/2017/211) for a fellowship.
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