Bicuspid Aortic Valve in 2 Model Species and Review of the Literature
Abstract
Bicuspid aortic valve (BAV) is the most common human congenital cardiac malformation. Although the etiology is unknown for most patients, formation of the 2 main BAV anatomic types (A and B) has been shown to rely on distinct morphogenetic mechanisms. Animal models of BAV include 2 spontaneous hamster strains and 27 genetically modified mouse strains. To assess the value of these models for extrapolation to humans, we examined the aortic valve...
Paper Details
Title
Bicuspid Aortic Valve in 2 Model Species and Review of the Literature
Published Date
Feb 21, 2020
Journal
Volume
57
Issue
2
Pages
321 - 331
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