Pattern Electroretinograms in Preperimetric and Perimetric Glaucoma.

Published on Jul 1, 2020in American Journal of Ophthalmology4.013
· DOI :10.1016/J.AJO.2020.02.008
Kyoung In Jung12
Estimated H-index: 12
(Catholic University of Korea),
Soo Ji Jeon7
Estimated H-index: 7
(Catholic University of Korea)
+ 2 AuthorsChan Kee Park27
Estimated H-index: 27
(Catholic University of Korea)
Abstract Purpose To investigate whether visual function can be graded in detail using pattern electroretinogram (PERG) in preperimetric to perimetric glaucoma Design Cross-sectional observational study Methods Twenty-six normal subjects, 113 preperimetric glaucoma patients (which included glaucoma suspect patients), and 52 early perimetric glaucoma patients with a mean deviation (MD) > -10dB were included. Structural and functional measurements were performed using spectral-domain optical coherence tomography and a commercial ERG stimulator, respectively. Results The average retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness were thinnest in perimetric group followed by the preperimetric group and the control group (P Conclusions PERG N95 amplitudes decreased from the control to preperimetric glaucoma and were reduced more in perimetric glaucoma. The functional assessment for detecting early glaucomatous damage could be complemented by PERG N95 amplitude. Usefulness of PERG parameters except N95 amplitude seemed to be limited in a clinical setting because of relatively low diagnostic performance in preperimetric glaucoma.
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