Pattern Electroretinograms in Preperimetric and Perimetric Glaucoma.

Published on Jul 1, 2020in American Journal of Ophthalmology4.013
· DOI :10.1016/J.AJO.2020.02.008
Kyoung In Jung12
Estimated H-index: 12
(Catholic University of Korea),
Soo Ji Jeon7
Estimated H-index: 7
(Catholic University of Korea)
+ 2 AuthorsChan Kee Park27
Estimated H-index: 27
(Catholic University of Korea)
Sources
Abstract
Abstract Purpose To investigate whether visual function can be graded in detail using pattern electroretinogram (PERG) in preperimetric to perimetric glaucoma Design Cross-sectional observational study Methods Twenty-six normal subjects, 113 preperimetric glaucoma patients (which included glaucoma suspect patients), and 52 early perimetric glaucoma patients with a mean deviation (MD) > -10dB were included. Structural and functional measurements were performed using spectral-domain optical coherence tomography and a commercial ERG stimulator, respectively. Results The average retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness were thinnest in perimetric group followed by the preperimetric group and the control group (P Conclusions PERG N95 amplitudes decreased from the control to preperimetric glaucoma and were reduced more in perimetric glaucoma. The functional assessment for detecting early glaucomatous damage could be complemented by PERG N95 amplitude. Usefulness of PERG parameters except N95 amplitude seemed to be limited in a clinical setting because of relatively low diagnostic performance in preperimetric glaucoma.
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Newest
#1André Carvalho Kreuz (USP: University of São Paulo)H-Index: 3
#2Carlos Gustavo De Moraes (CUMC: Columbia University Medical Center)H-Index: 35
Last. Mário Luiz Ribeiro Monteiro (USP: University of São Paulo)H-Index: 31
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To evaluate the ability of macular and multifocal (mf) pattern electroretinogram (PERG) to differentiate preperimetric glaucoma (PG) and glaucoma with hemifield loss (GHL) from controls, to compare the discrimination ability of PERG and fourier-domain optical coherence tomography (FD-OCT), and to assess the relationship between measurements.Standard automated perimetry, steady-state and transient PERG and mfPERG measurements were obtained from PG (n=14, 24 eyes), GHL (n=5, 7 eyes), and controls ...
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#1Kyoung In Jung (Catholic University of Korea)H-Index: 12
#2Chan Kee Park (Catholic University of Korea)H-Index: 27
Purpose To evaluate an effective functional strategy for detecting glaucomatous damage of the macula in preperimetric to perimetric glaucoma. Design Cross-sectional study. Methods Preperimetric glaucoma patients (n = 102) and perimetric glaucoma patients (n = 88) with isolated paracentral scotoma or combined paracentral scotoma were enrolled in this study. Global and sectoral mean sensitivities (MS) were evaluated using 10-2 standard automated perimetry (SAP) with a stimulus of sizes III (0.43-d...
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#1Barbara Cvenkel (Ljubljana University Medical Centre)H-Index: 12
#2Maja SustarH-Index: 10
Last. Darko Perovšek (Ljubljana University Medical Centre)H-Index: 4
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Purpose To evaluate discrimination ability of pattern electroretinography (PERG) and photopic negative response (PhNR) between early glaucoma and healthy controls, and their relationship with structural measurements using spectral-domain optical coherence tomography (SD-OCT).
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#1Guihua Xu (CUHK: The Chinese University of Hong Kong)H-Index: 11
#2Robert N. Weinreb (UCSD: University of California, San Diego)H-Index: 136
Last. Christopher Kai-Shun Leung (CUHK: The Chinese University of Hong Kong)H-Index: 55
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Objective To investigate the temporal relationship between optic nerve head (ONH) surface depression and retinal nerve fiber layer (RNFL) thinning measured by confocal scanning laser ophthalmoscopy (CSLO) and spectral-domain optical coherence tomography (SD-OCT), respectively, during the course of glaucoma progression. Design Prospective, longitudinal study. Participants A total of 146 eyes of 90 patients with glaucoma and 70 normal eyes of 35 healthy individuals followed for an average of 5.4 y...
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#1L.M. Pinto (UNIFESP: Federal University of São Paulo)H-Index: 4
#2Elaine de Paula Fiod Costa (UNIFESP: Federal University of São Paulo)H-Index: 12
Last. Augusto Paranhos (UNIFESP: Federal University of São Paulo)H-Index: 17
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RESULTS. The correlation coefficients for the threshold sensitivity measured with SAP and Stratus OCT ranged from 0.44 to 0.79, and those for Spectralis OCT ranged from 0.30 to 0.75. Regarding FDT matrix, the correlation ranged from 0.40 to 0.79 with Stratus OCT and from 0.39 to 0.79 with Spectralis OCT. Stronger correlations were found in the overall measurements and the arcuate sectors for both visual fields and OCT devices. A linear relationship was observed between FDT matrix sensitivity and...
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#1Hye-Young Shin (Catholic University of Korea)H-Index: 10
Last. Chan Kee ParkH-Index: 27
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PURPOSE. We explored and compared the relationships between the visual field (VF) sensitivities assessed by standard automated perimetry (SAP), and the ganglion cell–inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thicknesses as measured by Cirrus high-definition optical coherence tomography (HD-OCT) in glaucomatous eyes. METHODS. We enrolled 213 eyes of 213 patients with glaucoma. The thicknesses of the average/sectoral GCIPL and pRNFL were measured by Cirrus H...
46 CitationsSource
Aim To detect early glaucoma, Porciatti and Ventura suggested in 2004 the pattern electroretinogram (PERG) protocol “PERGLA” with the following features: (1) skin electrodes, (2) steady-state reversal (15 rps) of horizontal 1.6 cpd gratings and (3) Fourier-based analysis. We compared this to our “PERG Ratio” protocol which uses (1) corneal (DTL) electrodes, (2) nearly the same reversal rate, but 2 check sizes of 0.8° and 16° and (3) Fourier-based analysis using the ratio of amplitudes to the 2 c...
19 CitationsSource
#1Andrew J. Tatham (UCSD: University of California, San Diego)H-Index: 23
#2Robert N. Weinreb (UCSD: University of California, San Diego)H-Index: 136
Last. Felipe A. Medeiros (UCSD: University of California, San Diego)H-Index: 83
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Purpose To estimate retinal ganglion cell (RGC) losses associated with visible glaucomatous localized retinal nerve fiber layer (RNFL) defects. Design Observational cross-sectional study. Methods A multicenter study of 198 normal eyes (138 subjects) and 66 glaucomatous eyes (55 subjects) recruited from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study. All eyes underwent standard automated perimetry (SAP), spectral-domain optical coherence tomogra...
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#1Renato Lisboa (UCSD: University of California, San Diego)H-Index: 12
#2Augusto Paranhos (UNIFESP: Federal University of São Paulo)H-Index: 17
Last. Felipe A. Medeiros (UCSD: University of California, San Diego)H-Index: 83
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RESULTS. The three RNFL parameters with the largest AUCs were average RNFL thickness (0.89 6 0.03), inferior hemisphere average thickness (0.87 6 0.03), and inferior quadrant average thickness (0.85 6 0.03). The three ONH parameters with the largest AUCs were vertical cupto-disc ratio (0.74 6 0.04), rim area (0.72 6 0.05), and rim volume (0.72 6 0.05). The three macular parameters with the largest AUCs were GCC average thickness (0.79 6 0.04), GCC inferior thickness (0.79 6 0.05), and GCC superi...
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#1Michael R. Banitt (UM: University of Miami)H-Index: 11
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PURPOSE. We determined the time lag between loss of retinal ganglion cell function and retinal nerve fiber layer (RNFL) thickness. METHODS. Glaucoma suspects were followed for at least four years. Patients underwent pattern electroretinography (PERG), optical coherence tomography (OCT) of the RNFL, and standard automated perimetry testing at 6-month intervals. Comparisons were made between changes in all testing modalities. To compare PERG and OCT measurements on a normalized scale, we calculate...
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