Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

eLife7.70
Volume: 9
Published: Feb 26, 2020
Abstract
Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in new molecular and cellular functionality. We show here that sodium channels can implement a molecular leaky integrator, where the input signal is the membrane potential and the output is the...
Paper Details
Title
Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing
Published Date
Feb 26, 2020
Journal
Volume
9
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