Dendronized‐Polymer Disturbing Cells' Stress Protection by Targeting Metabolism Leads to Tumor Vulnerability

Metabolic demand of cancer is quite unique compared to normal tissues and this is an emerging hallmark of cancer, which brings a potential opportunity to discover drugs that target cancer cell metabolism. Herein, the development of a dendronized pyropheophorbide a (Ppa)‐conjugated polymer (DPP) is reported, and a linear Ppa‐conjugated polymer (LPP) is reported as a control. DPP is found to disturb cellular metabolism including increased energy...