Morphologic and histopathologic change of sodium iodate-induced retinal degeneration in adult rats.

Adult teleost fish are capable of regenerating their retinas following injury. In contrast, the adult mammalian retina has little capacity for regeneration. Here, we describe the morphologic and histopathologic course of sodium iodate (NaIO3) injection on rat retinas. A single dose of NaIO3 (50 mg/kg) was administered intravenously to adult Sprague-Dawley male rats. Control animals received sodium chloride. Morphologic and molecular changes...