This paper reviews recent advances regarding land-atmosphere-ocean coupling associated with the Tibetan Plateau (TP) and its climatic impacts. Thermal forcing over the TP interacts strongly with that over the Iranian Plateau, forming a coupled heating system that elevates the tropopause, generates a monsoonal meridional circulation over South Asia and creates conditions of large-scale ascent favorable for Asian summer monsoon development. TP heating leads to intensification and westward extension (northward movement) of the South Asian High (Atlantic Intertropical Convergence Zone), and exerts strong impacts on upstream climate variations from North Atlantic to West Asia. It also affects oceanic circulation and buoyancy fields via atmospheric stationary wave trains and air-sea interaction processes, contributing to formation of the Atlantic Meridional Overturning Circulation. The TP thermal state and atmospheric-oceanic conditions are highly interactive and Asian summer monsoon variability is controlled synergistically by internal TP variability and external forcing factors.