Original paper
CRISPR-engineered T cells in patients with refractory cancer
Abstract
CRISPR-Cas9 gene editing provides a powerful tool to enhance the natural ability of human T cells to fight cancer. We report a first-in-human phase 1 clinical trial to test the safety and feasibility of multiplex CRISPR-Cas9 editing to engineer T cells in three patients with refractory cancer. Two genes encoding the endogenous T cell receptor (TCR) chains, TCRα (TRAC) and TCRβ (TRBC), were deleted in T cells to reduce TCR mispairing and to...
Paper Details
Title
CRISPR-engineered T cells in patients with refractory cancer
Published Date
Feb 28, 2020
Journal
Volume
367
Issue
6481
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Notes
History