Interplay between compartmentalized NAD+ synthesis and consumption: a focus on the PARP family

Volume: 34, Issue: 5-6, Pages: 254 - 262
Published: Feb 6, 2020
Abstract
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for redox enzymes, but also moonlights as a substrate for signaling enzymes. When used as a substrate by signaling enzymes, it is consumed, necessitating the recycling of NAD+ consumption products (i.e., nicotinamide) via a salvage pathway in order to maintain NAD+ homeostasis. A major family of NAD+ consumers in mammalian cells are poly-ADP-ribose-polymerases (PARPs). PARPs...
Paper Details
Title
Interplay between compartmentalized NAD+ synthesis and consumption: a focus on the PARP family
Published Date
Feb 6, 2020
Volume
34
Issue
5-6
Pages
254 - 262
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