Preoperative CT-based radiomics combined with intraoperative frozen section is predictive of invasive adenocarcinoma in pulmonary nodules: a multicenter study

Objectives Develop a CT-based radiomics model and combine it with frozen section (FS) and clinical data to distinguish invasive adenocarcinomas (IA) from preinvasive lesions/minimally invasive adenocarcinomas (PM). Methods This multicenter study cohort of 623 lung adenocarcinomas was split into training ( n = 331), testing ( n = 143), and external validation dataset ( n = 149). Random forest models were built using selected radiomics features,...