Miniproteins as a Powerful Modality in Drug Development

Therapeutics based on miniprotein scaffolds can have antibody-like affinity and functionality while avoiding some of the liabilities of larger scaffolds, such as poor tissue or cell penetration, protease and reduction sensitivity, complex manufacturing and characterization, or (for antibodies) reliance on targets of poor host homology. Among miniproteins, three categories (hydrophobic core, cystine-reinforced, and chemically stabilized) emerge...