m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells
Abstract
Macroautophagy/autophagy is indispensable for testosterone synthesis in Leydig cells (LCs), and here we report a negative association between m6A modification and autophagy in LCs during testosterone synthesis. A gradual decrease of METTL14 (methyltransferase like 14) and an increase of ALKBH5 (alkB homolog 5, RNA demethylase) were observed in LCs during their differentiation from stem LCs to adult LCs. These events led to reduced mRNA...
Paper Details
Title
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells
Published Date
Jan 31, 2020
Journal
Volume
17
Issue
2
Pages
457 - 475
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