Parenchyma

Cerebrospinal fluid

Meningitis

Subarachnoid space

Metastasis

Meningeal carcinomatosis

Surgery

Dura mater

Radiology

Meninges

Pia mater

Solid tumor

Central nervous system

Internal medicine

Medicine

Leptomeninges

Cancer

Pathology

Journal of the Neurological Sciences

<h2>Abstract</h2> Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on LM arising from solid tumors with a goal of providing the reader an understanding of the epidemiology, pathophysiology, clinical presentation, prognostication, current management and future directions.

Leptomeningeal metastasis from solid tumors