Optimization of electrospinning process & parameters for producing defect-free chitosan/polyethylene oxide nanofibers for bone tissue engineering

Chitosan (CS) nanofibers were electrospun from aqueous chitosan solution using concentrated acetic acid solution as a solvent. Polyethylene oxide (PEO) with varying weight content from 10- 60 wt% was mixed with chitosan solution that acted as a plasticizer to improve spinability of the prepared chitosan solution. With the increase in PEO content from 10-50 wt% the viscosity of the resultant CS/PEO solution was decreased from 0.938 Pa-s to 0.272...