HSP70: an alarmin that does not induce high rates of preterm birth but does cause adverse neonatal outcomes

Preterm labor and birth are strongly associated with sterile intra-amniotic inflammation, a clinical condition that is proposed to be initiated by danger signals, or alarmins. The aim of this study was to investigate whether the intra-amniotic administration of the alarmin heat shock protein 70 (HSP70) induces preterm labor/birth and adverse neonatal outcomes.Pregnant mice received an intra-amniotic injection of 200 ng (n = 8), 400 ng (n = 6),...