Evolutionary biology

Biology

Gene

Cancer

Genome

Metastasis

Computational biology

Cancer research

Genetics

Cancer cell

Cancer Cell

Metastatic cancer is a major cause of death and remains largely incurable. A better understanding of metastasis is therefore desperately needed to improve prognosis for late-stage disease. Here, we survey the landscape of studies exploring the genomics of metastatic cancer. We consider evidence for genomic drivers of metastasis and explore studies investigating modes of metastatic spread.

Cancer Genome Evolutionary Trajectories in Metastasis