Original paper
Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia
Volume: 40, Issue: 12, Pages: 2505 - 2520
Published: Jan 7, 2020
Abstract
Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria and a potent inflammatory stimulus for the innate immune response via toll-like receptor (TLR) 4 activation. Type 2 diabetes is associated with changes in gut microbiota and impaired intestinal barrier functions, leading to translocation of microbiota-derived LPS into the circulatory system, a condition referred to as metabolic endotoxemia. We...
Paper Details
Title
Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia
Published Date
Jan 7, 2020
Volume
40
Issue
12
Pages
2505 - 2520
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