Journal of Cerebral Blood Flow and Metabolism
Papers 7,722
1 page of 773 pages (7,722 results)
#1MinJung Jang (UNIST: Ulsan National Institute of Science and Technology)
#2SoHyun Han (SKKU: Sungkyunkwan University)H-Index: 6
Last. HyungJoon Cho (UNIST: Ulsan National Institute of Science and Technology)H-Index: 20
view all 3 authors...
Quantitative measurement of cerebrospinal fluid (CSF) flow and volume and longitudinal monitoring of CSF dynamics provide insights into the compensatory characteristics of post-stroke CSF. In this study, we compared the MRI pseudo-diffusion index (D*) of live and sacrificed rat brains to confirm the effect of ventricular CSF flow on diffusion signals. We observed the relationship between the CSF peak velocities and D* through Monte Carlo (MC) simulations to further understand the source of D* co...
The development of new treatment strategies for intracranial aneurysms (IAs) has been and continues to be a major interest in neurovascular research. Initial treatment concepts were mainly based on a physical-mechanistic disease understanding for IA occlusion (lumen-oriented therapies). However, a growing body of literature indicates the important role of aneurysm wall biology (wall-oriented therapies) for complete IA obliteration. This systematic literature review identified studies that explor...
#1Ariel Diaz (Yerkes National Primate Research Center)H-Index: 9
#2Yena Woo (Yerkes National Primate Research Center)H-Index: 2
Last. Manuel Yepes (Yerkes National Primate Research Center)H-Index: 38
view all 6 authors...
Ischemic tolerance is a phenomenon whereby transient exposure to a non-injurious preconditioning stimulus triggers resistance to a subsequent lethal ischemic insult. Despite the fact that not only ...
Small vessel disease is associated with age, mean blood pressure (MAP) and blood pressure pulsatility (PP). We used data from the UK Biobank cohort study to determine the relative importance of MAP versus PP driving white matter injury within individual white matter tracts, particularly in the anterior and posterior vascular territory. The associations between blood pressure and diffusion indices in 27 major tracts were analysed using unadjusted and fully-adjusted general linear models and mixed...
#1W. Hudson Robb (VUMC: Vanderbilt University Medical Center)
#2Omair A. Khan (VUMC: Vanderbilt University Medical Center)H-Index: 5
Last. Angela L. Jefferson (VUMC: Vanderbilt University Medical Center)H-Index: 50
view all 13 authors...
Oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are markers of cerebral oxygen homeostasis and metabolism that may offer insights into abnormal changes in brain aging. The present study cross-sectionally related OEF and CMRO2 to cognitive performance and structural neuroimaging variables among older adults (n = 246, 74 ± 7 years, 37% female) and tested whether apolipoprotein E (APOE)-e4 status modified these associations. Main effects of OEF and CMRO2 were null (p-...
#1Osian Llwyd (University of Leicester)H-Index: 3
#2Jui-Lin Fan (University of Auckland)H-Index: 1
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The ischaemic penumbra is sensitive to alterations in cerebral perfusion. A myriad of drugs are used in acute ischaemic stroke (AIS) management, yet their impact on cerebral haemodynamics is poorly understood. As part of the Cerebral Autoregulation Network led INFOMATAS project (Identifying New Targets for Management and Therapy in Acute Stroke), this paper reviews some of the most common drugs a patient with AIS will come across and their potential influence on cerebral haemodynamics with a par...
#1Yasushi Hattori (Takeda)H-Index: 2
#2Chie SekiH-Index: 18
Last. Makoto HiguchiH-Index: 66
view all 9 authors...
Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase that cleaves monoacylglycerols into fatty acids and is a potential target for the novel treatment of CNS disorders related to the endo...
#1Bharath Chelluboina (UW: University of Wisconsin–Madison)H-Index: 5
#2Anil K Chokkalla (UW: University of Wisconsin–Madison)H-Index: 5
Last. Raghu Vemuganti (VA : United States Department of Veterans Affairs)H-Index: 50
view all 8 authors...
The role of tenascin-C (TNC) in ischemic stroke pathology is not known despite its prognostic association with cerebrovascular diseases. Here, we investigated the effect of TNC knockdown on post-stroke brain damage and its putative mechanism of action in adult mice of both sexes. Male and female C57BL/6 mice were subjected to transient middle cerebral artery occlusion and injected (i.v.) with either TNC siRNA or a negative (non-targeting) siRNA at 5 min after reperfusion. Motor function (beam wa...
#1Elisa Vazquez-Liebanas (Uppsala University)H-Index: 2
#2Khayrun Nahar (Uppsala University)H-Index: 9
Last. Maarja Andaloussi Mäe (Uppsala University)H-Index: 12
view all 6 authors...
Platelet-derived growth factor B (PDGFB) released from endothelial cells is indispensable for pericyte recruitment during angiogenesis in embryonic and postnatal organ growth. Constitutive genetic loss-of-function of PDGFB leads to pericyte hypoplasia and the formation of a sparse, dilated and venous-shifted brain microvasculature with dysfunctional blood-brain barrier (BBB) in mice, as well as the formation of microvascular calcification in both mice and humans. Endothelial PDGFB is also expres...
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