Photoreceptors are the first-order neurons of the visual pathway, converting light into electrical signals. Rods and cones are the two main types of photoreceptors in the mammalian retina. Rods are specialized for sensitivity at the expense of resolution and are responsible for vision in dimly lit conditions. Cones are responsible for high acuity central vision and colour vision. Many human retinal diseases are characterized by a progressive loss of photoreceptors. Photoreceptors consist of four...
Last. Marius Ader(TUD: Dresden University of Technology)H-Index: 25
view all 3 authors...
Sehbeeintrachtigungen und Erblindung aufgrund des Verlusts von Photorezeptoren stellen einen der Hauptgrunde fur Behinderungen in industrialisierten Gesellschaften dar. Wahrend Stabchenphotorezeptoren Seheindrucke unter schwachen Lichtverhaltnissen vermitteln, liefern Zapfenphotorezeptoren fokussierte visuelle Eindrucke bei Tageslicht und erlauben die Wahrnehmung von Farben. Verschiedene therapeutische Strategien, zu denen auch zellbasierte Interventionen zahlen, werden derzeit zur Behandlung ei...
Several retinal degenerative diseases cause vision loss and retinal cell death. Currently, people face prolonged exposure to digital screens, rendering vision protection from light exposure a critical topic. In this study, we designed a complex lutein formula (CLF) by combining several natural compounds: Calendula officinalis, Lycium barbarum, Vaccinium myrtillus, Cassia obtusifolia, and Rhodiola rosea. In addition, we evaluated the protective effects of the formula on retinal functions in an an...
Last. Ofra Benny(HUJI: Hebrew University of Jerusalem)H-Index: 22
view all 4 authors...
Abstract In today’s modern pharmacologic approach to treating sight-threatening retinal vascular disorders, there is an increasing demand for a compact, mobile, lightweight and cost-effective fluorescein fundus camera to document the effects of antiangiogenic drugs on laser-induced choroidal neovascularization (CNV) in mice and other experimental animals. We have adapted the use of the Kowa Genesis Df Camera to perform Fundus Fluorescein Angiography (FFA) in mice. The 1 kg, 28 cm high camera has...
N-methyl-N-nitrosourea (MNU) has been reported to induce photoreceptor-specific degeneration with minimal inner retinal impact in small animals in vivo. Pending its use within a retinal transplantation paradigm, we here explore the effects of MNU on outer and inner retinal neurons and glia in an in vitro large animal model of retinal degeneration. The previously described degenerative culture explant model of adult porcine retina was used and compared with explants receiving 10 or 100 μg/ml MNU ...
Last. Yuqiang Wang(JNU: Jinan University)H-Index: 25
view all 10 authors...
Edaravone (EDA) is clinically used for treatment of acute ischemic stroke in Japan and China due to its potent free radical-scavenging effect. However, it has yet to be determined whether EDA can attenuate iodoacetic acid- (IAA-) induced neuronal death in vitro. In the present study, we investigated the effect of EDA on damage of IAA-induced primary cerebellar granule neurons (CGNs) and its possible underlying mechanisms. We found that EDA attenuated IAA-induced cell injury in CGNs. Moreover, ED...
Last. Leslie A. Lyons(UC Davis: University of California, Davis)H-Index: 43
view all 9 authors...
The domestic cat (Felis silvestris catus) is a popular companion animal1,2 as well as an important model for human disease.3–5 Due to their more recent domestication,6–8 cats have relatively fewer breeds than dogs,9,10 and, accordingly, fewer inherited diseases have been identified in the domestic cat.4,11 However, several ophthalmic diseases in domestic cats have a genetic basis.12 Three distinct inherited forms of progressive retinal atrophy (PRA) are well documented in domestic cats: an early...
Last. Peter Walter(RWTH Aachen University)H-Index: 134
view all 6 authors...
Background To characterize the effects of intravitreal injections of iodoacetic acid (IAA) in comparison to its systemic application as a measure to induce unilateral photoreceptor degeneration.
This work was supported by the Australian Research Council (ARC)through its Special Research Initiative (SRI) in Bionic Vision Science and Technology grant to Bionic Vision Australia (BVA) and by the NHMRC project grant (APP1021042;APP1061419) to ELF by Retina Australia. CERA receives Operational Infrastructure Support from the Victorian Government and is supported by NHMRC Centre for Clinical Research Excellence Award 529923.
Last. Mingliang Pu(PKU: Peking University)H-Index: 25
view all 7 authors...
Iodoacetic acid (IAA) has been applied to different species to acutely induce photoreceptor degeneration. The purpose of the present study was to use this toxin to thoroughly eliminate photoreceptors and induce complete blindness in the cat. IAA was delivered by single ear vein injection (20 mg kg−1). Six months after the IAA treatment, functional evaluations including pupillary light reflex (PLR), electroretinogram (ERG), visual behavior tests were performed. Morphological examinations were car...