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Original paper

Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

eLife6.40
Volume: 8
Published: Dec 24, 2019
Abstract
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins remains unresolved, and the functions of many viral proteins are incompletely characterised. We performed a mass spectrometry-based interactome analysis of 169 tagged, stably-expressed canonical strain Merlin HCMV...
Paper Details
Title
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Published Date
Dec 24, 2019
Journal
Volume
8
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