Original paper
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Abstract
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins remains unresolved, and the functions of many viral proteins are incompletely characterised. We performed a mass spectrometry-based interactome analysis of 169 tagged, stably-expressed canonical strain Merlin HCMV...
Paper Details
Title
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Published Date
Dec 24, 2019
Journal
Volume
8