Skin in the diagnostics game: Wearable biosensor nano- and microsystems for medical diagnostics

Published on Feb 1, 2020in Nano Today20.722
· DOI :10.1016/J.NANTOD.2019.100828
Muamer Dervisevic17
Estimated H-index: 17
(Monash University),
María D. Alba25
Estimated H-index: 25
(Monash University)
+ 1 AuthorsNicolas H. Voelcker62
Estimated H-index: 62
Abstract The skin, as the largest and most accessible organ in the human body, contains biofluids rich in biomarkers useful not only in diagnosis and monitoring of diseases, but also in profiling an individual’s wellbeing. Advancements in micro- and nanotechnology research have underpinned the development of multifunctional wearable sensing devices. Those sensors may allow monitoring of physiological parameters from different skin sections such as epidermis, dermis and hypodermis by sampling various bodily fluids. Our review summarizes current advances in wearable biosensors for on-skin analysis of sweat, transdermal monitoring of interstitial fluid and analysis of subcutaneous fluids via implanted devices. The review is divided into three main parts describing biosensors acting on the different skin sections. Each part focuses on recent scientific and technological advancements in the wearable biosensing field by highlighting critical challenges as well as providing information on how these barriers are being addressed by the research community.
📖 Papers frequently viewed together
3 Authors (Mahshid Padash, ..., Sandro Carrara)
4 Authors (Shun Ye, ..., Shengtai Bian)
#1Mehmet SenelH-Index: 30
#2Muamer Dervisevic (Monash University)H-Index: 17
Last. Nicolas H. Voelcker (Monash University)H-Index: 62
view all 3 authors...
Abstract Here we present the simple and effective fabrication method of an array of gold microneedles (AuMNs) via the casting of conductive gold ink. To demonstrate the potential of MN arrays as electrochemical biosensors we functionalized AuMNs with an epoxy- and ferrocene-functional polymeric mediator and covalently immobilised urease. The performance of the MN array biosensor for urea detection was assessed in artificial interstitial fluid and epidermal/skin mimic, both spiked with urea. The ...
#1Jie Gao (SYSU: Sun Yat-sen University)H-Index: 5
#2Wenzheng Huang (SYSU: Sun Yat-sen University)H-Index: 2
Last. Lelun Jiang (SYSU: Sun Yat-sen University)H-Index: 22
view all 5 authors...
Abstract The development of versatile and low-cost biosensor system for rapid and simultaneous detection of multiple blood metabolites is highly demanded for home healthcare. We developed a flexible microneedle electrode array-based biosensor (MEAB) and a multi-channel portable electrochemical analyzer (MPEA) for the simultaneous detection of glucose, uric acid, and cholesterol. Microneedle electrode array (MEA) was fabricated on the flexible substrate using magnetorheological drawing lithograph...
#1Michael Mayer (University of Regensburg)H-Index: 6
#2Antje J. Baeumner (University of Regensburg)H-Index: 44
The Internet of Things (IoT) is a megatrend that cuts across all scientific and engineering disciplines and establishes an integrating technical evolution to improve production efficiencies and daily human life. Linked machines and sensors use decision-making routines to work toward a common product or solution. Expanding this technical revolution into the value chain of complex areas such as agriculture, food production, and healthcare requires the implementation and connection of sophisticated...
#1Yiran Yang (California Institute of Technology)H-Index: 11
#2Wei Gao (California Institute of Technology)H-Index: 68
Wearable biosensors have received tremendous attention over the past decade owing to their great potential in predictive analytics and treatment toward personalized medicine. Flexible electronics could serve as an ideal platform for personalized wearable devices because of their unique properties such as light weight, low cost, high flexibility and great conformability. Unlike most reported flexible sensors that mainly track physical activities and vital signs, the new generation of wearable and...
#1Eldhose Skaria (University of Brighton)H-Index: 2
#2Bhavik Anil PatelH-Index: 27
Last. Keng Wooi Ng (Newcastle University)H-Index: 12
view all 4 authors...
Minimally invasive, reliable and low-cost in vivo biosensors that enable real-time detection and monitoring of clinically relevant molecules and biomarkers can significantly improve patient health care. Microneedle array (MNA)-based electrochemical sensors offer exciting prospects in this respect, as they can sample directly from the skin. However, their acceptability is dependent on developing a highly scalable and cost-effective fabrication strategy. In this work, we evaluated the potential fo...
#1Jason Heikenfeld (UC: University of Cincinnati)H-Index: 46
#2Andrew J. Jajack (UC: University of Cincinnati)H-Index: 7
Last. Benjamin A KatchmanH-Index: 1
view all 7 authors...
Peripheral biochemical monitoring involves the use of wearable devices for minimally invasive or noninvasive measurement of analytes in biofluids such as interstitial fluid, saliva, tears and sweat. The goal in most cases is to obtain measurements that serve as surrogates for circulating analyte concentrations in blood. Key technological developments to date include continuous glucose monitors, which use an indwelling sensor needle to measure glucose in interstitial fluid, and device-integrated ...
#2Alan Campbell (UCSD: University of California, San Diego)H-Index: 140
Wearable biosensors are garnering substantial interest due to their potential to provide continuous, real-time physiological information via dynamic, noninvasive measurements of biochemical markers in biofluids, such as sweat, tears, saliva and interstitial fluid. Recent developments have focused on electrochemical and optical biosensors, together with advances in the noninvasive monitoring of biomarkers including metabolites, bacteria and hormones. A combination of multiplexed biosensing, micro...
#1E. V. Karpova (MSU: Moscow State University)H-Index: 9
#2Elizaveta V Shcherbacheva (MSU: Moscow State University)H-Index: 1
Last. Arkady A. Karyakin (MSU: Moscow State University)H-Index: 54
view all 6 authors...
We propose monitoring of diabetes through continuous analysis of undiluted sweat immediately after its excretion using a flow-through glucose biosensor. The used biosensors are based on Prussian Blue and glucose oxidase immobilized in perfluorosulfonated ionomer or gel of alkoxysilane; the resulting sensitivity with the latter reaches in batch mode 0.23 A M–1 cm–2, and the calibration range is from 1 μM to 1 mM (flow-through mode). On the basis of the glucose tolerance test known to be a clinica...
#1Kwang-Bok Kim (Samsung)H-Index: 11
#2Won-Chul Lee (PNU: Pusan National University)H-Index: 8
Last. Yoon-Bo Shim (PNU: Pusan National University)H-Index: 63
view all 6 authors...
Abstract A minimally invasive wireless biosensor was developed for glucose monitoring using human blood. The sensor probe was shaped in a microneedle array with a cyclic olefin copolymer. FAD-glucose oxidase (GOx) was covalently bound to a terthiophene carboxylic acid (TCA) monomer followed by electropolymerization on a gold-coated microneedle (AuMN) array using the potential cycling method (AuMN/pTCA-GOx). The formation of the sensing probe layer on the needle was confirmed by employing electro...
#1Chandana Kolluru (Georgia Institute of Technology)H-Index: 5
#2Mikayla Williams (Georgia Institute of Technology)H-Index: 3
Last. Mark R. Prausnitz (Georgia Institute of Technology)H-Index: 103
view all 6 authors...
Minimally invasive point-of-care diagnostic devices are of great interest for rapid detection of biomarkers in diverse settings. Although blood is the most common source of biomarkers, interstitial fluid (ISF) is an alternate body fluid that does not clot or contain red blood cells that often complicate analysis. However, ISF is difficult to collect. In this study, we assessed the utility of a microneedle patch to sample microliter volumes of ISF in a simple and minimally invasive manner. We dem...
Cited By32
#1Arnab Shit (KNUT: Korea National University of Transportation)H-Index: 14
#2Seul Gi Kim (KNUT: Korea National University of Transportation)H-Index: 4
Last. Sung Young Park (KNUT: Korea National University of Transportation)H-Index: 37
view all 0 authors...
Abstract null null A self-repairable and reusable self-powered electronic skin sensor is developed from NIR/pH-responsive polymer dot (PD) embedded hydrogel with amplified mechanical and electrochemical properties after self-healing. The pH/NIR-controlled mechanical, electrochemical and self-healing performance of the designed hydrogel is achieved by manipulating the hydrogen bond formation with tunable mobility from the PD components. The hydrogel formed at pH 7.4, after treatment with pH 10 an...
#1Muamer Dervisevic (Monash University)H-Index: 17
#2María D. Alba (Monash University)H-Index: 25
Last. Nicolas H. VoelckerH-Index: 62
view all 5 authors...
Abstract null null Electrochemical devices for transdermal monitoring of key biomarkers are the potential next frontier of wearable technologies for point-of-care disease diagnosis. Cancer is the leading cause of death worldwide with estimated 10 million deaths in 2018 according to the World Health Organization. Breast cancer is one of the five most common causes of cancer death with over two million cases recorded in 2018. Early diagnosis and prognosis based on monitoring of breast cancer bioma...
#1Hadi Mirzajani (Koç University)
#2Fariborz Mirlou (Koç University)
Last. Levent Beker (Koç University)H-Index: 10
view all 5 authors...
As the tear is noninvasively and continuously available, it has been turned into a convenient biological interface as a wearable medical device for out-of-hospital and self-monitoring applications. Recent progress in integrated circuits (ICs) and biosensors coupled with wireless data communication techniques have led to the implementation of smart contact lenses that can continuously sample tear fluid, analyze physiological conditions, and wirelessly transmit data to an electronic device such as...
#1Ahmad Ali (UVAS: University of Veterinary and Animal Sciences)H-Index: 6
#2Muhammad Ijaz (UVAS: University of Veterinary and Animal Sciences)H-Index: 13
Last. Muhammad Anas Naeem (UVAS: University of Veterinary and Animal Sciences)H-Index: 2
view all 13 authors...
Nanotechnology is the discipline and technology of small and specific things that are < 100 nm in size. Because of their extremely miniscule size, any changes in their chemical and physical structure may show higher reactivity and solubility than larger particles. Nanotechnology plays a vital role in every field of life. It is considered one of the most bleeding edge field of scientific research. It has already several applications in a myriad of disciplines while its application in the field of...
#2Sumit Kumar (LPU: Lovely Professional University)H-Index: 10
#3Pramod Kumar (IISc: Indian Institute of Science)H-Index: 5
Abstract null null Wearable (bio)sensors driven through emerging three-dimensional (3D) printing technologies are currently considered as the next-generation tools for various healthcare applications due to their exciting characteristics such as high stretchability, super flexibility, low cost, ultra-thinness, and lightweight. In this context, 3D printing, an emerging advanced additive manufacturing technology, has revolutionized the concept of free form construction and end-user customization o...
#1Ehsan Nazarzadeh Zare (Damghan University)H-Index: 27
#2Tarun Agarwal (IIT-KGP: Indian Institute of Technology Kharagpur)H-Index: 18
Last. Tapas K. Maiti (IIT-KGP: Indian Institute of Technology Kharagpur)H-Index: 53
view all 15 authors...
Abstract null null Polypyrrole is an example of inherently electrically conductive polymer that is employed in the biomedical arena because of its low cost, excellent electroconductive properties, and good biocompatibility. Because many body tissues respond to electrical fields, polypyrrole-based nanocomposites have become an important class of bio-conductive material. Nanocomposites prepared by blending polypyrrole with other biopolymers or nanomaterials show marked improvements in physicochemi...
#1Roozbeh Ghaffari (NU: Northwestern University)H-Index: 38
#2Da Som Yang (NU: Northwestern University)H-Index: 4
Last. Tyler R. Ray (U.H.: University of Hawaii at Manoa)H-Index: 18
view all 9 authors...
Skin-interfaced wearable systems with integrated colorimetric assays, microfluidic channels, and electrochemical sensors offer powerful capabilities for noninvasive, real-time sweat analysis. This Perspective details recent progress in the development and translation of novel wearable sensors for personalized assessment of sweat dynamics and biomarkers, with precise sampling and real-time analysis. Sensor accuracy, system ruggedness, and large-scale deployment in remote environments represent ke...
#9Ennio Tasciotti (Università telematica San Raffaele)H-Index: 1
Intracellular delivery of advanced therapeutics, including biologicals and supramolecular agents, is complex because of the natural biological barriers that have evolved to protect the cell. Efficient delivery of therapeutic nucleic acids, proteins, peptides and nanoparticles is crucial for clinical adoption of emerging technologies that can benefit disease treatment through gene and cell therapy. Nanoneedles are arrays of vertical high-aspect-ratio nanostructures that can precisely manipulate c...
Abstract null null Precision, sustainability and intelligence are the development trend of livestock farming in the future. Precision livestock farming (PLF) is a key step to achieve the sustainable development of smart farms, but it is still in the initial stage and has broad prospects. In order to realize precise livestock production, it is necessary to speed up the popularization of intelligent technologies such as environmental control, disease early warning, precise feeding and remote diagn...
#1Tao Sheng (ZJU: Zhejiang University)H-Index: 2
#2Bowen Luo (ZJU: Zhejiang University)H-Index: 1
Last. Zhen GuH-Index: 82
view all 7 authors...
Vaccine administration by subcutaneous or intramuscular injection is the most commonly prescribed route for inoculation, however, it is often associated with some deficiencies such as low compliance, high professionalism, and risk of infection. Therefore, the application of microneedles for vaccine delivery has gained widespread interests in the past few years due to its high compliance, minimal invasiveness, and convenience. This review focuses on recent advances in the development and applicat...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.