Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives
Abstract
Two series of novel derivatives of AD-2, an active ginsenoside derived from ginseng were designed and synthesized. Five human cancer cell lines (MGC-803, SGC-7901, A549, MCF-7, PC-3 cells) and one normal ovarian cell IOSE144 were employed to evaluate the anti-proliferative activity. Most of derivatives possessed obvious enhanced activity compared with AD-2. Among them, compound 4c displayed the most excellent activity in all tested cancer cell...
Paper Details
Title
Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives
Published Date
Feb 1, 2020
Volume
187
Pages
111964 - 111964
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