The toughness chitosan-PVA double network hydrogel based on alkali solution system and hydrogen bonding for tissue engineering applications.

Published on Mar 1, 2020in International Journal of Biological Macromolecules5.162
· DOI :10.1016/J.IJBIOMAC.2019.12.186
Shichao Bi9
Estimated H-index: 9
(Ocean University of China),
Jianhui Pang9
Estimated H-index: 9
(Ocean University of China)
+ 3 AuthorsXiguang Chen61
Estimated H-index: 61
(Ocean University of China)
Abstract Biocompatibility and mechanical properties have always been important indicators for the application of hydrogel materials in tissue engineering. In this work, a high strength and toughness chitosan-poly (vinyl alcohol) (PVA) DN (double network) hydrogel based on multiple hydrogen bonding interactions was prepared by applying the simple freezing-heating alternate treatment to the chitosan-PVA alkaline solution. The PVA first network was prepared by freeze crystallization, and the chitosan second network was constructed by raising the chitosan/KOH/urea temperature to 45 °C. The dynamic hydrogen bonding presented in the first PVA network and the second chitosan network given the hydrogel superior compressive (60%-230 KPa), tensile (152 KPa-360%), recoverability (90.77% after 5 cycles) and anti-swelling properties. The results of in vitro cell compatibility and in vivo subcutaneous implantation in rats both indicated that the chitosan-PVA DN hydrogel had the ability to promote cell attachment and wound healing. This DN hydrogel based on hydrogen bonding is expected to be applied in the tissue engineering repair. In addition, the hydrogel preparation process is simple and non-toxic, which provides a reference for the production of green and safe tissue engineering hydrogels.
📖 Papers frequently viewed together
11 Authors (Yanqin Wang, ..., Weiyi Chen)
17 Citations
5 Citations
53 Citations
#1Guang Ren (UL: University of Limerick)H-Index: 10
#2Cian Clancy (UL: University of Limerick)H-Index: 2
Last. Maurice N. Collins (UL: University of Limerick)H-Index: 32
view all 6 authors...
Abstract The use of chitosan as a potential excipient in pharmaceutical formulations for the delivery of drugs produced via direct compression tableting has been investigated. Chitosan, N-cinnamyl substituted O-amine functionalized chitosan (cinnamyl-chitosan) and microcrystalline cellulose (MCC) were formulated, alongside acetaminophen as the active pharmaceutical ingredient (API), and magnesium stearate (Mg-St) as lubricant in a series of formulated blends. A control blend of MCC, acetaminophe...
47 CitationsSource
#1Zhihui Hu (Xi'an University of Architecture and Technology)H-Index: 2
#2Liang Zhang (Xi'an University of Architecture and Technology)H-Index: 11
Last. Yue Li (Xi'an University of Architecture and Technology)H-Index: 40
view all 6 authors...
Abstract Microbial contamination has evolved as a life-threatening problem afflicting people due to various diseases caused by pathogenic bacteria in drinking water. Thus developing novel antibacterial materials is an urgent need. Herein, a chitosan (CTS)/ biochar-nanosilver (C-Ag) antibacterial composite was prepared by a method of CTS-coated on C-Ag obtained through a facile high-temperature carbonization process using corn straw as the carbon substrate. The results from FT-IR, XRD, SEM and TG...
16 CitationsSource
#1Shichao Bi (Ocean University of China)H-Index: 9
#2Shihao Hu (Ocean University of China)H-Index: 7
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 8 authors...
Abstract The novel solvent (0.25 M KOH/0.01 M urea alkaline solution) was used to successfully dissolve chitosan without freezing-thawing cycles, for the first time. The results from XRD, FTIR, and 13CNRM proved that KOH/urea solution could destroy the hydrogen bonds between chitosan chains more efficiently than NaOH/urea solution. The dynamic light scattering, rheology, viscosity and elemental analysis confirmed that the KOH/urea hydrogen-bonded chitosan complex had a better thermal stability a...
17 CitationsSource
#1Mahroo KhaleghiH-Index: 6
#2Fatemeh ManiH-Index: 1
Last. Meisam ShabanianH-Index: 25
view all 8 authors...
4 CitationsSource
#1Soyon KimH-Index: 15
#2Zhong-Kai Cui (Southern Medical University)H-Index: 19
Last. Min LeeH-Index: 37
view all 6 authors...
Tuning hydrogel degradation enables effective and successful tissue regeneration by modulating cellular behaviors and matrix formation. In this work, we develop a novel degradable hydrogel scaffold on the basis of a unique enzyme–substrate complex by photocrosslinking. Chitosan and lysozyme are chemically modified with methacrylate moieties to be tethered in hydrogels, and in the presence of riboflavin initiator, these hydrogels are cured by blue light irradiation. The incorporation of lysozyme ...
32 CitationsSource
#1Zheng Zhang (NBU: Ningbo University)H-Index: 4
#2Ting-Ting Li (NBU: Ningbo University)H-Index: 24
Last. Zhiyong Guo (NBU: Ningbo University)H-Index: 22
view all 8 authors...
Supramolecular hydrogels are increasingly fascinating soft polymeric materials formed by noncovalent interactions. Poly(vinyl alcohol) (PVA), chitosan and graphite oxide (GO), good biocompatibility, and nontoxicity, are green materials with potential applications in biomaterials. Herein, a dual cross-link supramolecular hydrogel of PVA/chitosan in the presence of GO was prepared. Without addition of any organic cross-linker, the dual-network PVA/chitosan hydrogel was obtained, namely GO nanoshee...
9 CitationsSource
#1Wenbin Wang (Fudan University)H-Index: 5
#2Hongxi Zhang (Fudan University)H-Index: 2
Last. Mingxin Ye (Fudan University)H-Index: 52
view all 4 authors...
Abstract Novel magnetic chitosan/poly (vinyl alcohol) hydrogel beads (MCPHBs) were prepared through a freezing-thawing method. FTIR, XRD, VSM, TGA and SEM were used to characterize the structure and morphology of MCPHBs. XRD and VSM results indicated that MCPHBs had enough response to meet the needs of magnetic separation even with only little amounts of magnetic nanoparticles. On the other hand, adsorption of methyl orange (MO) was studied. The adsorption capacity was mainly affected by pH valu...
23 CitationsSource
#1Si Yu Zheng (ZJU: Zhejiang University)H-Index: 7
#2Yangyang Shen (ZJU: Zhejiang University)H-Index: 2
Last. Qiang Zheng (ZJU: Zhejiang University)H-Index: 55
view all 8 authors...
84 CitationsSource
#1M.D. Figueroa-Pizano (Universidad de Sonora)H-Index: 1
#2Itziar Vélaz (University of Navarra)H-Index: 16
Last. María Elisa Martínez-Barbosa (Universidad de Sonora)H-Index: 2
view all 7 authors...
Abstract The freezing-thawing is an advantageous method to produce hydrogels without crosslinking agents. In this study chitosan-poly(vinyl alcohol) (CS-PVA) hydrogels were prepared by varying the freezing conditions and composition, which affect the final characteristics of the products. The swelling degree, morphology, porosity, and diflunisal drug loading, as well as the drug release profiles were evaluated. The hydrogel swelling ratio was found to be mainly affected by the CS content, the nu...
45 CitationsSource
#1Xinyu Liu (THU: Tsinghua University)H-Index: 9
#2Mengmeng Sun (THU: Tsinghua University)H-Index: 9
Last. Weiping Gao (THU: Tsinghua University)H-Index: 21
view all 7 authors...
Conjugating a hydrophilic and protein-resistant polymer to a protein is a widely used strategy to extend the in vivo half-life of the protein; however, the benefit of the half-life extension is usually limited by the bioactivity decrease. Herein we report a supramolecular self-assembly strategy of site-specific in situ polymerization induced self-assembly (SI-PISA) to address the dilemma. An amphiphilic block copolymer (POEGMA-PHPMA) was directly grown from the C-terminus of an important therape...
38 CitationsSource
Cited By23
#1Fei Yu (Shanghai Ocean University)H-Index: 18
#2Peiyu Yang (Shanghai Ocean University)
Last. Jie Ma (Tongji University)H-Index: 39
view all 0 authors...
Abstract null null Double-network (DN) hydrogel is consist of two intertwined crosslinked networks, with a balanced mechanical performance combining high strength and toughness. In addition to the excellent mechanical properties brought about by the double-network structure, it can also possess good anti-swelling and self-healing properties, laying a good foundation for the application of hydrogels in the environment. Recently, research on the application of double-network hydrogels in the envir...
#1Kai Chen (CUMT: China University of Mining and Technology)H-Index: 8
#2Qin Chen (CUMT: China University of Mining and Technology)
Last. Dekun Zhang (CUMT: China University of Mining and Technology)H-Index: 22
view all 7 authors...
Polyvinyl alcohol (PVA) hydrogels with excellent characteristics are considered as promising cartilage replacement materials. However, there are still some main issues to be solved for PVA hydrogel, such as poor mechanical strength and disordered structure. Inspired by the highly ordered structure of biological soft tissues such as articular cartilage, here, we prepared a high-strength but anisotropic polyvinyl alcohol-nanohydroxyapatite-polyacrylic acid (PVA-HA-PAA) composite hydrogel by direct...
#2Jiankang LiH-Index: 1
Last. Jingan Li (Zhengzhou University)H-Index: 9
view all 5 authors...
Wounds have become one of the causes of death worldwide. The metabolic disorder of the wound microenvironment can lead to a series of serious symptoms, especially chronic wounds that bring great pain to patients, and there is currently no effective and widely used wound dressing. Therefore, it is important to develop new multifunctional wound dressings. Hydrogel is an ideal dressing candidate because of its 3D structure, good permeability, excellent biocompatibility, and ability to provide a moi...
#1Yu Lei (University of Paris)
#2Imane Boucenna (University of Paris)H-Index: 5
Last. Alain Ponton (University of Paris)H-Index: 15
view all 0 authors...
#1Zhanbin Feng (ZJU: Zhejiang University)
#2Ziteng Zhang (ZJU: Zhejiang University)
Last. Xing-Hong Zhang (ZJU: Zhejiang University)
view all 4 authors...
#1Xianwen Song (CSU: Central South University)H-Index: 1
#2Ting He (CSU: Central South University)H-Index: 12
Last. Yi Zhang (CSU: Central South University)H-Index: 18
view all 7 authors...
#1Yifeng Yu (WHU: Wuhan University)
#2Xiaofeng Yu (HUST: Huazhong University of Science and Technology)
Last. Ying Wan (HUST: Huazhong University of Science and Technology)H-Index: 32
view all 5 authors...
Amino-functionalized mesoporous silica nanoparticles with radially porous architecture were optimally synthesized, and they were used together with silk fibroin and chitosan to produce a type of covalently crosslinked composite hydrogel using genipin as a crosslinker. The optimally achieved composite gels were found to be thermo-responsive at physiological temperature and pH with well-defined injectability. They were also detected to have mechanically strong and elastic characteristics. In addit...
#1Mina Ghafouri Azar (University of West Bohemia)
#2Jagan Mohan Dodda (University of West Bohemia)H-Index: 5
Last. Tomáš Remiš (University of West Bohemia)H-Index: 2
view all 7 authors...
1 CitationsSource
#1Yale Luck Nunes (UFC: Federal University of Ceará)H-Index: 1
#2Fernando Lima de Menezes (UFC: Federal University of Ceará)H-Index: 2
Last. José C. S. dos Santos (University for International Integration of the Afro-Brazilian Lusophony)H-Index: 35
view all 15 authors...
Abstract Chitosan is one of the most abundant natural polymer worldwide, and due to its inherent characteristics, its use in industrial processes has been extensively explored. Because it is biodegradable, biocompatible, non-toxic, hydrophilic, cheap, and has good physical-chemical stability, it is seen as an excellent alternative for the replacement of synthetic materials in the search for more sustainable production methodologies. Thus being, a possible biotechnological application of Chitosan...
7 CitationsSource