Evolution and Diversity of Assembly-Line Polyketide Synthases

Volume: 119, Issue: 24, Pages: 12524 - 12547
Published: Dec 15, 2019
Abstract
Assembly-line polyketide synthases (PKSs) are among the most complex protein machineries known in nature, responsible for the biosynthesis of numerous compounds used in the clinic. Their present-day diversity is the result of an evolutionary path that has involved the emergence of a multimodular architecture and further diversification of assembly-line PKSs. In this review, we provide an overview of previous studies that investigated PKS...
Paper Details
Title
Evolution and Diversity of Assembly-Line Polyketide Synthases
Published Date
Dec 15, 2019
Volume
119
Issue
24
Pages
12524 - 12547
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